Conjunctival nevi and melanoma: multiparametric immunohistochemical analysis, including p16, sox10, hmb45, and ki-67.

Publication date: Jul 21, 2020

The role of p16 in the diagnosis and prognosis of conjunctival melanocytic lesions in the context of other clinical and immunohistochemical parameters has not been systematically explored. This study was conducted to determine whether p16 is a useful parameter in the diagnosis and prognosis of conjunctival melanocytic nevi and melanoma, either independently or as a component of immunohistochemical panels. Sixty one patients underwent 61 biopsies for conjunctival melanocytic lesions between 2014-2018. Pathologic diagnoses were melanoma (n=25, 41%), nevus (n=21, 34%), and conjunctival melanocytic lesion of uncertain malignant potential (n=15, 25%). The biopsies were assessed for expression of p16, SOX10, HMB45, and Ki-67. In a multivariable model, the parameters most predictive of melanoma vs. nevus were diffuse HMB45 staining [odds ratio (OR)=45, confidence interval (CI)=4.4-457, P=.02] and p16 nuclear H-score

Concepts Keywords
Biopsies
Confidence Interval
Conjunctival
Immunohistochemical
Lesion
Malignant
Melanocytic Nevi
Melanoma
Nevi
Nevus
Odds Ratio
Prognosis
Staining

Semantics

Type Source Name
disease MESH melanocytic nevi
disease MESH diagnosis
pathway KEGG Melanoma
disease MESH melanoma
disease MESH nevi

Original Article

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