Radiobiology data of melanoma cells after low-energy neutron irradiation and boron compound administration.

Publication date: Sep 01, 2020

The cold neutron beam at the PF1b line at the Institut Laue-Langevin (ILL), without fast neutrons and a low contribution of gamma rays, is a very suitable facility to measure cell damage following low-energy neutron irradiation. The biological damage associated with the thermal and the boron doses can be obtained in order to evaluate the relative biological effectiveness (RBE) for Boron Neutron Capture Therapy. Three different experiments were carried out on the A375 melanoma cell line: the first one in a hospital LINAC, to obtain the reference radiation data, and the other two at the ILL, in which the damage to cells with and without boron compounds added was measured.

Concepts Keywords
Beam Boron
Boron Baryons
Energy Chemical elements
Fast Neutrons Neutron facilities
Gamma Rays Radiation therapy
Hospital Chemistry
LINAC Medical physics
Melanoma Natural sciences
Neutron Physical sciences
Radiation Radiation
Radiobiology A375 melanoma
Relative Biological Effectiveness Radiobiology melanoma
Institut Laue–Langevin


Type Source Name
disease MESH melanoma
pathway KEGG Melanoma
drug DRUGBANK Boron
drug DRUGBANK Tricyclazole

Original Article

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