Accelerated decline in white matter microstructure in subsequently impaired older adults and its relationship with cognitive decline.

Accelerated decline in white matter microstructure in subsequently impaired older adults and its relationship with cognitive decline.

Publication date: Sep 23, 2020

INTRODUCTION: Little is known about longitudinal decline in white matter (WM) microstructure and its associations with cognition in preclinical Alzheimers disease (AD). METHODS: Longitudinal diffusion tensor imaging and neuropsychological testing from 50 older adults who subsequently developed mild cognitive impairment or dementia (subsequently impaired, SI) and 200 cognitively normal controls. Rates of WM decline were compared between groups using voxel-wise linear mixed-effects models. Associations between change in WM and cognition were examined. RESULTS: SI had faster decline in fractional anisotropy (FA) in the right inferior fronto-occipital fasciculus (R.IFOF) and bilateral splenium of the corpus callosum. Decline in R.IFOF FA was related to decline in verbal memory, visuospatial ability, processing speed, and MMSE (p[≤] 0.05). Decline in bilateral splenium FA was related to decline in verbal fluency, processing speed, and MMSE (p[≤] 0.05). DISCUSSION: Accelerated regional WM decline is characteristic of preclinical AD and related to domain specific cognitive decline.

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Concepts Keywords
Acceleration Clinical dementia
Aging Introduction Dementia
Amyloid BJ Cognitive impairment
APOE Preclinical Alzheimers disease
Apolipoprotein Common dementia
Asymptomatic Carrier members difference
Atrophy Impaired participants
Autosomal Dominant Control
Axons Microstructural decline
Baltimore Faster decline
Battery Decline processing speed
Behavioral Neuroscience Cognitive status groups
Beta Amyloid Normal imaging
Biomarkers Possibility individuals
Brain Carrier relatives
Caguas Anatomy
Chi Square Test Brain
Cholesterol Commissural fiber
Cingulum Corpus callosum
Clinical Trials Aphasias
Cognition Learning disabilities
Cognitive Cerebrum
Conservative Diffusion MRI
Corpus Callosum Uncinate fasciculus
Covariance White matter
Cross Cingulum
Default Mode Network Alzheimer’s disease
Dementia Neuroscience
Dependent Variable Radiation
Diabetes Mellitus Antibodies
Diffusion Acquisition protocols
Diffusion Tensor Imaging Html
Disability Magnetic resonance imaging
DTI Spectroscopy
Eddy Currents Neurosurgery
Episodic Memory
Evian
Executive Attention
Executive Functioning
Fornix
Fronto
Gerontology
Gray Matter
Hypertension
Informed Consent
Magnitude
Maryland
Massachusetts
Mathworks
MathWorks
MATLAB
MCI
Medial Temporal Lobe
Mental Examination
Microstructure
Mild Cognitive Impairment
MRI
Multiple Comparisons
Myelin
Nashville
Natick
Neurodegenerative
Neurofilaments
Neuropsychological Test
Neuropsychological Testing
Obesity
Occipital
Orbitofrontal
Oxford
Oxford United
Peak
Philips
Phosphorylated
Pipeline
Progressive
Skeleton
Spatial Statistics
Splenium
Symptom
Tensor
Tesla
Vanderbilt
Visuospatial
Voxel
Voxels
White Matter

Semantics

Type Source Name
disease MESH cognitive decline
disease MESH dementia
disease MESH Aging
disease MESH death
drug DRUGBANK Water
disease MESH Hypertension
disease MESH Elevated Cholesterol
disease MESH risk factors
disease MESH diabetes mellitus
disease MESH obesity
disease MESH men
drug DRUGBANK Coenzyme M
drug DRUGBANK Methionine
drug DRUGBANK 5-amino-1 3 4-thiadiazole-2-thiol
disease MESH atrophy
disease MESH diagnoses
disease MESH pathology
drug DRUGBANK Etoperidone
drug DRUGBANK Aducanumab
disease MESH abnormalities
disease MESH Shock

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