Epidermal Growth Factor in the CNS: A Beguiling Journey from Integrated Cell Biology to Multiple Sclerosis. An Extensive Translational Overview.

Publication date: Nov 05, 2020

This article reviews the wealth of papers dealing with the different effects of epidermal growth factor (EGF) on oligodendrocytes, astrocytes, neurons, and neural stem cells (NSCs). EGF induces the in vitro and in vivo proliferation of NSCs, their migration, and their differentiation towards the neuroglial cell line. It interacts with extracellular matrix components. NSCs are distributed in different CNS areas, serve as a reservoir of multipotent cells, and may be increased during CNS demyelinating diseases. EGF has pleiotropic differentiative and proliferative effects on the main CNS cell types, particularly oligodendrocytes and their precursors, and astrocytes. EGF mediates the in vivo myelinotrophic effect of cobalamin on the CNS, and modulates the synthesis and levels of CNS normal prions (PrPs), both of which are indispensable for myelinogenesis and myelin maintenance. EGF levels are significantly lower in the cerebrospinal fluid and spinal cord of patients with multiple sclerosis (MS), which probably explains remyelination failure, also because of the EGF marginal role in immunology. When repeatedly administered, EGF protects mouse spinal cord from demyelination in various experimental models of autoimmune encephalomyelitis. It would be worth further investigating the role of EGF in the pathogenesis of MS because of its multifarious effects.

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Concepts Keywords
Astrocytes Spinal cord demyelination
Autoimmune MS
Cerebrospinal Fluid Branches of biology
Cobalamin Glial cells
Demyelinating Diseases Remyelination
Demyelination Oligodendrocyte
EGF Myelitis
Encephalomyelitis Demyelinating disease
Epidermal Growth Factor Astrocyte
Extracellular Matrix Epidermal growth factor
Immunology Neural stem cell
Multiple Sclerosis Oligodendrocyte progenitor cell
Multipotent Prions
Myelin
Neuroglial
Neurons
Oligodendrocytes
Pathogenesis
Pleiotropic
Prions
Reservoir
Spinal Cord
Vivo

Semantics

Type Source Name
disease MESH Multiple Sclerosis
disease MESH demyelinating diseases
drug DRUGBANK Cobalamin
disease MESH encephalomyelitis
disease MESH Growth
disease MESH Sclerosis
drug DRUGBANK Trestolone
disease MESH CNS diseases
disease MESH hypoxia
disease MESH middle cerebral artery occlusion
disease MESH brain tumors
drug DRUGBANK L-Phenylalanine
drug DRUGBANK Diflunisal
drug DRUGBANK L-Glutamine
disease MESH pathology
drug DRUGBANK Choline
drug DRUGBANK Glutamic Acid
disease MESH immuno
drug DRUGBANK Dopamine
drug DRUGBANK Basic Fibroblast Growth Factor
pathway KEGG MAPK signaling pathway
drug DRUGBANK Broxuridine
drug DRUGBANK Ornithine
drug DRUGBANK Putrescine
drug DRUGBANK Rasagiline
drug DRUGBANK Methoxy polyethylene glycol-epoetin beta
pathway KEGG Endocytosis
drug DRUGBANK L-Lysine
disease MESH chemically induced
drug DRUGBANK Serine
drug DRUGBANK L-Threonine
drug DRUGBANK Coenzyme M
drug DRUGBANK Liothyronine
drug DRUGBANK Uridine
drug DRUGBANK Methylergometrine
disease MESH abnormalities
disease MESH tics
drug DRUGBANK Isoprenaline
drug DRUGBANK Adenosine phosphate
drug DRUGBANK gamma-Aminobutyric acid
drug DRUGBANK L-Leucine
disease MESH polyp
disease MESH hyperplasia
disease MESH autoimmune response
disease MESH infection
disease MESH subacute combined degeneration
disease MESH nutritional status
disease MESH death
disease MESH diagnosis
disease MESH autoimmune disease
drug DRUGBANK Aminosalicylic Acid
drug DRUGBANK Somatotropin
drug DRUGBANK L-Tyrosine
disease MESH Relapsing remitting multiple sclerosis
drug DRUGBANK Tretinoin
disease MESH immune disease
drug DRUGBANK Potassium
drug DRUGBANK Tretamine
drug DRUGBANK Nerve Growth Factor
drug DRUGBANK Naproxen
pathway KEGG Axon regeneration
drug DRUGBANK Chondroitin sulfate
disease MESH neurological disorders
drug DRUGBANK Fibroblast growth factor-1
drug DRUGBANK Thrombin
disease MESH GGF2
drug DRUGBANK Glial growth factor 2
disease MESH schizophrenia
drug DRUGBANK Calcium
drug DRUGBANK Methylcobalamin
disease MESH ischemia
disease MESH aging
disease MESH neurodegenerative disorders
drug DRUGBANK Thyroglobulin
drug DRUGBANK Esomeprazole
drug DRUGBANK Cyanocobalamin
drug DRUGBANK Copper
drug DRUGBANK Azacitidine
disease MESH Experimental allergic encephalomyelitis
drug DRUGBANK Ilex paraguariensis leaf

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