MRI Characteristics of NMO, MOG and MS Related Optic Neuritis.

MRI Characteristics of NMO, MOG and MS Related Optic Neuritis.

Publication date: Jan 04, 2021

Acute isolated optic neuritis can be the initial presentation of demyelinating inflammatory central nervous system disease related to multiple sclerosis (MS), neuromyelitis optica (NMO) or myelin oligodendrocyte glycoprotein antibody disease (MOG-AD). In addition to the well-characterized brain and spinal cord imaging features, important and characteristic differences in the radiologic appearance of the optic nerves in these disorders are being described, and magnetic resonance imaging (MRI) of the optic nerves is becoming an essential tool in the differential diagnosis of optic neuritis. Whereas typical demyelinating optic neuritis is a relatively mild and self-limited disease, atypical optic neuritis in NMO and MOG-AD is potentially much more vision-threatening and merits a different treatment approach. Thus, differentiation based on MRI features may be particularly important during the first attack of optic neuritis, when antibody status is not yet known. This review discusses the optic nerve imaging in the major demyelinating disorders with an emphasis on clinically relevant differences that can help clinicians assess and manage these important neuro-ophthalmic disorders. It also reviews the utility of optic nerve MRI as a prognostic indicator in acute optic neuritis.

Concepts Keywords
Antibody Magnetic resonance imaging
Brain Optic nerve imaging
Central Nervous System Demyelinating disorders
Differential Diagnosis Autoimmune diseases
Glycoprotein Neurological disorders
Magnetic Resonance Imaging Nervous system
MOG Branches of biology
MRI Myelin oligodendrocyte glycoprotein
Multiple Sclerosis Optic neuritis
Myelin Multiple sclerosis
Neuritis Optic nerve
Neuromyelitis Optica Demyelinating disease
Oligodendrocyte MOG antibody disease
Ophthalmic Magnetic resonance imaging
Optic Nerve MRI
Optic Nerves
Optic Neuritis
Spinal Cord


Type Source Name
disease MESH Optic Neuritis
disease MESH multiple sclerosis
disease MESH neuromyelitis optica
disease MESH diagnosis
disease MESH demyelinating disorders

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