Peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis.

Peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis.

Publication date: Jan 08, 2021

Increasing evidence suggests that abnormal regulation of neurotrophic factors is involved in the etiology and pathogenesis of Autism Spectrum Disorder (ASD). However, clinical data on neurotrophic factor levels in children with ASD were inconsistent. Therefore, we performed a systematic review of peripheral blood neurotrophic factors levels in children with ASD, and quantitatively summarized the clinical data of peripheral blood neurotrophic factors in ASD children and healthy controls. A systematic search of PubMed and Web of Science identified 31 studies with 2627 ASD children and 4418 healthy controls to be included in the meta-analysis. The results of random effect meta-analysis showed that the peripheral blood levels of brain-derived neurotrophic factor (Hedges’ g?=?0.302; 95% CI?=?0.014 to 0.591; P?=?0.040) , nerve growth factor (Hedges’ g?=?0.395; 95% CI?=?0.104 to 0.686; P?=?0.008) and vascular endothelial growth factor (VEGF) (Hedges’ g?=?0.097; 95% CI?=?0.018 to 0.175; P?=?0.016) in children with ASD were significantly higher than that of healthy controls, whereas blood neurotrophin-3 (Hedges’ g?=??-?0.795; 95% CI?=??-?1.723 to 0.134; P?=?0.093) and neurotrophin-4 (Hedges’ g?=?0.182; 95% CI?=??-?0.285 to 0.650; P?=?0.445) levels did not show significant differences between cases and controls. Taken together, these results clarified circulating neurotrophic factor profile in children with ASD, strengthening clinical evidence of neurotrophic factor aberrations in children with ASD.

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Concepts Keywords
Aberrations Neurochemistry
Autism Spectrum Disorder Peptide hormones
Blood Growth factors
Etiology Developmental neuroscience
Meta Analysis Branches of biology
Nerve Growth Factor Autism spectrum
Neurotrophic Factor Nerve growth factor
Neurotrophic Factors Neurotrophin
Neurotrophin Brain-derived neurotrophic factor
Neurotrophin 3 Neurotrophic factors


Type Source Name
disease MESH autism spectrum disorder
drug DRUGBANK Nerve Growth Factor
drug DRUGBANK Coenzyme M
drug DRUGBANK (S)-Des-Me-Ampa
disease MESH neurodevelopmental disorders
disease MESH autistic disorder
disease MESH Aspergers syndrome
disease MESH Developmental Disabilities
disease MESH development
drug DRUGBANK Ademetionine
drug DRUGBANK Methionine
disease MESH abnormalities
disease MESH schizophrenia
disease MESH diagnosis
drug DRUGBANK L-Valine
drug DRUGBANK Water
disease MESH Risk factors
drug DRUGBANK Isoxaflutole
disease MESH oxidative stress
drug DRUGBANK Serotonin
drug DRUGBANK Fluoxetine
disease MESH mental retardation
disease MESH attention deficit hyperactivity disorder
drug DRUGBANK Trestolone
disease MESH Rett syndrome
drug DRUGBANK Risperidone
disease MESH insulin resistance
pathway KEGG Insulin resistance
drug DRUGBANK Dopamine
disease MESH tryptophan
drug DRUGBANK L-Tryptophan
drug DRUGBANK Adenosine
disease MESH major depressive disorder
drug DRUGBANK Nitric Oxide
disease MESH pathology
disease MESH depression
disease MESH syndrome
disease MESH tic
disease MESH Landau Kleffner syndrome
disease MESH epilepsy

Original Article

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