Reduced serum SIRT1 levels in patients with Parkinson's disease: a cross-sectional study in China.

Reduced serum SIRT1 levels in patients with Parkinson's disease: a cross-sectional study in China.

Publication date: May 01, 2021

Parkinson’s disease (PD) is a movement disorder lacking of validated biomarkers. Experimental studies support the potential value of silent information regulator 1 (SIRT1) in neurodegeneration including PD. We aim to detect the serum levels of SIRT1 in PD patients in order to assess its value as a potential biomarker of PD. Fifty-eight PD patients and 91 healthy controls were included. Serum SIRT1 was determined by enzyme-linked immunosorbent assay (ELISA) and compared between controls and PD patients. Spearman correlation coefficient was analyzed to study the relationship between serum SIRT1 and clinical parameters in PD patients. Receiver operating characteristic (ROC) analysis was conducted to assess the diagnostic value of serum SIRT1 in PD identification. Serum SIRT1 was significantly reduced in PD patients compared with controls. According to the ROC curve, the optimal cut-off point was 0. 47 ng/ml with the sensitivity of 71% and specificity of 71%. Serum SIRT1 level was related to age of onset, disease duration, Hoehn-Yahr staging scale (H-Y stage), Unified Parkinson’s Disease Rating Scale III (UPDRS III), and Mini-Mental State Examination (MMSE). PD patients with cognitive impairment had lower serum SIRT1 than those with normal cognitive ability. Serum SIRT1 was reduced in PD patients and associated with disease severity and cognitive function. Our results indicate that SIRT1 may be a potential biomarker for PD.

Concepts Keywords
Biomarkers Transcription factors
China Parkinson’s disease
Elisa Medicine
Immunosorbent Branches of biology
Neurodegeneration PD movement disorder
Parkinson Cut
Serum Disease
MMSE cognitive impairment
Sirtuin 1


Type Source Name
disease MESH movement disorder
drug DRUGBANK Saquinavir
disease MESH cognitive impairment

Original Article

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