Core prescription pattern of Chinese herbal medicine for depressive disorders in Taiwan: a nationwide population-based study.

Core prescription pattern of Chinese herbal medicine for depressive disorders in Taiwan: a nationwide population-based study.

Publication date: Sep 01, 2021

Depressive disorders (DD) affect not only mood and behavior but also various physical functions. Traditional Chinese medicine (TCM) has been shown to have some benefits in treating DD. However, one formula or one single herb might be not show high efficacy when used to treat depression. Thus, this study aimed to examine the core prescription pattern of Chinese herbal medicine (CHM) among patients with DD in Taiwan as a reference for related research and clinical applications. All patients, who had been diagnosed with major depressive disorder or minor depression or dysthymia without any other baseline diseases and had at least one CHM outpatient clinical visit from 2002 to 2011, were extracted from three randomly sampled cohorts, namely the 2000, 2005 and 2010 cohorts of the National Health Insurance Research Database (NHIRD) of Taiwan. The collected data was analyzed to explore the patterns of herbal products. There were 197,146 patients with a diagnosis of DD and of these 1806 subjects had only a diagnosis of DD and utilized CHM. The most common formula was Gan-Mai-Da-Zao-Tang (12. 19%), while Suan-Zao-Ren (3. 99%) was the most commonly prescribed single herb. The core pattern of prescriptions consisted of a combination of Gan-Mai-Da-Zao-Tang, Jia-Wei-Xiao-Yao-San, Chai-Hu-Jia-Long-Gu-Mu-Li-Tang, He-Huan-Pi, Yuan-Zhi and Shi-Chang-Pu. This study describes the CHM core prescription pattern used to treat patients in Taiwan with DD and it is a potential candidate for study in future pharmacological or clinical trials targeting DD.

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Concepts Keywords
Chinese Dysthymia
Herbal Self
Outpatient Mind
Branches of biology
Psychiatric diagnosis
Related clinical applications
Herbal products
Insurance database
Herbal medicine
Major depressive disorder


Type Source Name
disease MESH depressive disorders
disease MESH depression
disease MESH major depressive disorder
disease MESH dysthymia
disease MESH diagnosis
drug DRUGBANK (S)-Des-Me-Ampa
drug DRUGBANK Coenzyme M
disease MESH anxiety
disease MESH suicide
drug DRUGBANK Saquinavir
disease MESH eating
drug DRUGBANK Pentaerythritol tetranitrate
disease MESH chronic diseases
disease MESH hypertension
disease MESH cancer
disease MESH weight gain
drug DRUGBANK Aspartame
disease MESH privacy
drug DRUGBANK Ranitidine
disease MESH separated
drug DRUGBANK Angelica archangelica root
drug DRUGBANK Scutellaria baicalensis root
drug DRUGBANK Ginseng
drug DRUGBANK Rehmannia glutinosa root
drug DRUGBANK Schisandra chinensis fruit
drug DRUGBANK Platycodon grandiflorus root
drug DRUGBANK Anemarrhena asphodeloides root
drug DRUGBANK Tangerine peel
drug DRUGBANK Calcium
drug DRUGBANK Potassium
drug DRUGBANK Salvia miltiorrhiza root
disease MESH sleep
disease MESH abnormalities
drug DRUGBANK Corticosterone
disease MESH insomnia
disease MESH borderline personality disorder
disease MESH migraine
drug DRUGBANK gamma-Aminobutyric acid
disease MESH Lifestyle
drug DRUGBANK Norepinephrine
disease MESH sleep disorders
disease MESH Yin Deficiency
disease MESH sleep latency
drug DRUGBANK Magnesium
drug DRUGBANK Curcumin
disease MESH memory disorders
disease MESH syndromes
drug DRUGBANK Ferric pyrophosphate citrate
disease MESH Mental Disorders
disease MESH cognitive impairment
drug DRUGBANK Guanosine
disease MESH premenstrual dysphoric disorder
drug DRUGBANK Trestolone
drug DRUGBANK Ozone
disease MESH dementia
drug DRUGBANK Ethanol
disease MESH pancreatitis
drug DRUGBANK Scopolamine
drug DRUGBANK Piperine
drug DRUGBANK Water
drug DRUGBANK Carboxyamidotriazole
disease MESH chronic hepatitis

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