Risk factors for positive sentinel lymph node, lymphatic or hematogenous dissemination over time in patients with cutaneous melanoma.

Publication date: Jul 01, 2021

The aim of the present study was to assess the influence of localization, age or sex and histopathological characteristics upon the chance of developing lymphatic or hematogenous metastatic spread over time, or a positive sentinel lymph node in cutaneous melanoma patients. Patients from the Department of Dermatology, County Emergency Hospital Cluj-Napoca (Cluj-Napoca, Romania), presenting with cutaneous melanoma confirmed histopathologically and a SPECT/CT or lymphoscintigraphic examination to detect the sentinel lymph node, were included in the present study. Our results revealed that Breslow index >2 mm [odds ratio (OR)=4. 22, 95% confidence interval (CI) (1. 12; 15. 93)], presence of ulceration [OR=6. 01, 95% CI (1. 87; 19. 35)], and positive sentinel lymph node [for at least one sentinel lymph node OR=3. 58, 95% CI (1. 06; 12. 04)] were risk factors for hematogenous metastases. All these, except for the Breslow index >2 mm, were demonstrated to be a risk factor for lymphatic spread metastases over time. Ulceration and male sex also represented risk factors for a positive sentinel lymph node, men having a higher risk of developing sentinel lymph nodes than women [adjusted OR=2. 27, 95% CI (1. 00; 5. 13)]. In conclusion, the predictors that influence the occurrence of lymphatic or hematogenous metastases may differ, ulceration and positive sentinel lymph node being common for both types of metastatic spread, while Breslow index being a significant predictor only for hematogenous metastases. Male sex and the presence of ulceration were demonstrated to be significant risk factors for positive sentinel lymph nodes.

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Concepts Keywords
Ct Medical specialties
Lymphoscintigraphic Lymphatic system
Romania Clinical medicine
Breast cancer
Sentinel lymph node
Axillary lymph nodes


Type Source Name
disease MESH lymphatic metastasis
disease MESH Emergency
pathway KEGG Melanoma
disease MESH melanoma
disease MESH Risk factors

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