The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival.

Publication date: Jul 02, 2021

Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages in cancer progression. Here we show that the diversity of the TCR of tumor infiltrating T cell at baseline is prognostic in various cancers, whereas the TCR clonality of T cell infiltrating metastatic melanoma pre-treatment is predictive for activity and efficacy of PD1 blockade immunotherapy.

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Concepts Keywords
Cancer Tumor-infiltrating lymphocytes
Immunotherapy Lymphocytes
Pd1 Oncology
Predictive Immune system
Tcr Clinical medicine
Medical specialties


Type Source Name
disease MESH tumor
disease MESH melanoma
pathway KEGG Melanoma
drug DRUGBANK Coenzyme M
disease MESH death
disease MESH recurrence
disease MESH biopsy
disease MESH adenoma
disease MESH thymoma
pathway REACTOME Immune System
disease MESH noma
drug DRUGBANK Ethanol
drug DRUGBANK Water
drug DRUGBANK Saquinavir
disease MESH estrogen
drug DRUGBANK Nivolumab
disease MESH carcinoma

Original Article

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