SQSTM1/p62 droplet -mediated autophagosome formation:insights into Huntington disease.

Publication date: Jul 19, 2021

Huntington disease (HD) manifests a unique macroautophagy/autophagy defect: the presense of cytosolic autophagosomes without substrates or so-called “empty” autophagosomes. It was proposed that mutant HTT (huntingtin; mHTT) disrupts cargo recognition by the selective autophagy receptor SQSTM1/p62 thus leading to the failure of cargo sequestration by phagophores, the precursors to autophagosomes. Here we looked at recent discoveries that liquid-like SQSTM1 droplets can serve as platforms for autophagosome formation, and discussed possible alternative mechanisms for “empty” autophagosome formation in HD inspired by these findings.

Concepts Keywords
Autophagosomes Huntingtin
Disease Sequestosome 1
Huntingtin MTOR
Huntington Programmed cell death
Mutant Autophagosome
Cell death
Cell biology
Branches of biology


Type Source Name
pathway KEGG Autophagy
pathway REACTOME Macroautophagy
pathway KEGG Huntington disease
disease MESH Huntington disease

Original Article

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