Cannabinoids and their derivatives in struggle against melanoma.

Publication date: Jul 15, 2021

Melanoma is one of the most aggressive malignances in human. Recently developed therapies improved overall survival rate, however, the treatment of melanoma still remains a challenging issue. This review attempts to summarize recent advances in studies on cannabinoids used in the setting of melanoma treatment. Searches were carried out in PubMed, Google Scholar, Scopus, Research Gate. Conclusions after analysis of available data suggest that cannabinoids limit number of metastasis, and reduce growth of melanoma. The findings indicate that cannabinoids induce apoptosis, necrosis, autophagy, cell cycle arrest and exert significant interactions with tumor microenvironment. Cannabinoids should be rather considered as a part of multi-targeted anti-tumor therapy instead of being standalone agent. Moreover, cannabinoids are likely to improve quality of life in patients with cancer, due to different supportive effects, like analgesia and/or anti-emetic effects. In this review, it was pointed out that cannabinoids may be potentially useful in the melanoma therapy. Nevertheless, due to limited amount of data, great variety of cannabinoids available and lack of clinical trials, further studies are required to determine an exact role of cannabinoids in the treatment of melanoma.

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Concepts Keywords
Cancer Health
Cannabinoids Branches of biology
Google Cannabinoids
Improved CB1
Microenvironment Tumor microenvironment
Melanoma treatment
Melanoma therapy
Designer drugs


Type Source Name
disease MESH melanoma
pathway KEGG Melanoma
disease MESH growth
pathway KEGG Apoptosis
pathway KEGG Autophagy
disease MESH tumor

Original Article

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