Publication date: May 26, 2021
The spatial functional chronnectome is an innovative mathematical model designed to capture dynamic features in the organization of brain function derived from resting-state functional magnetic resonance imaging (rs-fMRI) data. Measurements of dynamic functional connectivity (dFC) have been developed from this model to quantify the brain dynamical self-reconfigurations at different spatial and temporal scales. This study examined whether two spatiotemporal dFC quantifications were linked to late adolescence-onset major depressive disorder (AO-MDD), and scaled with depression and symptom severity measured with the Montgomery-Asberg depression rating scale (MADRS) Methods: Thirty-five AO-MDD patients (21+/-6y) and fifty-three age- and gender-matched healthy young participants (20+/-3y) underwent 3T MRI structural and rs-fMRI acquisitions. The chronnectome here comprised seven individualized functional networks portrayed along 132 temporal overlapping windows, each framing 110s of resting brain activity Results: Based on voxelwise analyses, AO-MDD patients demonstrated significantly reduced temporal variability within the bilateral prefrontal cortex in five functional networks including the limbic network, the default-mode network (DMN) and frontoparietal network (FPN). Furthermore, the limbic network appeared to be particularly involved in this sample, and was associated with MADRS scores, and its progressive dynamic inflexibility was linked to sadness. DMN and FPN dynamics scaled with negative thoughts and neurovegetative symptoms, respectively Conclusions: This triple-network imbalance could delay spatiotemporal integration, while across-subject symptom variability would be network-specific. Therefore, the present approach supports that brain network dynamics underlie patients’ symptom heterogeneity in AO-MDD.
|disease||MESH||major depressive disorder|