Sleep Disorders in Children With Autism Spectrum Disorder: Insights From Animal Models, Especially Non-human Primate Model.

Publication date: Feb 27, 2021

Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder with deficient social skills, communication deficits and repetitive behaviors. The prevalence of ASD has increased among children in recent years. Children with ASD experience more sleep problems, and sleep appears to be essential for the survival and integrity of most living organisms, especially for typical synaptic development and brain plasticity. Many methods have been used to assess sleep problems over past decades such as sleep diaries and parent-reported questionnaires, electroencephalography, actigraphy and videosomnography. A substantial number of rodent and non-human primate models of ASD have been generated. Many of these animal models exhibited sleep disorders at an early age. The aim of this review is to examine and discuss sleep disorders in children with ASD. Toward this aim, we evaluated the prevalence, clinical characteristics, phenotypic analyses, and pathophysiological brain mechanisms of ASD. We highlight the current state of animal models for ASD and explore their implications and prospects for investigating sleep disorders associated with ASD.

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Concepts Keywords
Autism Developmental psychology
Decades Neurological disorders
Neurodevelopmental Autism
Parent Developmental neuroscience
Sleep Psychiatric diagnosis
Branches of biology
Autism spectrum
Sleep disorder
Developmental disorder
Neurodevelopmental disorder


Type Source Name
disease MESH Sleep Disorders
disease MESH Autism Spectrum Disorder
disease MESH neurodevelopmental disorder
disease MESH sleep
disease MESH development
disease MESH autism

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