Month: March 2022

March 31, 2022March 31, 2022

Protein kinase inhibitor responses in uveal melanoma reflects a diminished dependency on PKC-MAPK signaling.

Melanoma Literature

Publication date: Mar 29, 2022 Uveal melanoma (UM) is a rare cancer arising from melanocytes in the uveal tract of the eye. Despite effective primary treatment, there is no approved ... Read more

March 31, 2022March 31, 2022

Clinical characteristics and treatment outcomes of primary malignant melanoma of esophagus: a single center experience.

Melanoma Literature

Publication date: Mar 29, 2022 Primary malignant melanoma of esophagus (PMME) is an extremely rare disease with poor prognosis. We aimed to determine the clinical characteristics and treatment outcomes of ... Read more

March 31, 2022March 31, 2022

ICL-Net: Global and Local Inter-pixel Correlations Learning Network for Skin Lesion Segmentation.

Melanoma Literature

Publication date: Mar 30, 2022 Skin lesion segmentation is a fundamental procedure in computer-aided melanoma diagnosis. However, due to the diverse shape, variable size, blurry boundary, and noise interference of ... Read more

March 31, 2022March 31, 2022

Reference genes for qPCR-based miRNA expression profiling in 14 human tissues.

Melanoma Literature

Publication date: Mar 30, 2022 MicroRNAs (miRNAs) are promising biomarkers for the diagnosis and prognosis of various diseases. Quantitative PCR is the most frequently used method of measuring miRNA expression ... Read more

March 31, 2022March 31, 2022

Dynamic tracing of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs.

Melanoma Literature

Publication date: Mar 30, 2022 Synthetic sugar analogs are widely applied in metabolic oligosaccharide engineering (MOE) and as novel drugs to interfere with glycoconjugate biosynthesis. However, mechanistic insights on their ... Read more

March 31, 2022March 31, 2022

Tumor in the Crossfire: Inhibiting TGF-β to Enhance Cancer Immunotherapy.

Melanoma Literature

Publication date: Mar 30, 2022 Cancer immunotherapy using monoclonal antibodies targeting immune checkpoints has undoubtedly revolutionized the cancer treatment landscape in the last decade. Immune checkpoint inhibitors can elicit long-lasting, ... Read more

March 31, 2022March 31, 2022

Global Burden of Cutaneous Melanoma in 2020 and Projections to 2040.

Melanoma Literature

Publication date: Mar 30, 2022 Despite many cases being preventable, cutaneous melanoma remains the most serious skin cancer worldwide. Understanding the scale and profile of the disease is vital to ... Read more

March 31, 2022March 31, 2022

Expert Consensus on the Use of Prognostic Gene Expression Profiling Tests for the Management of Cutaneous Melanoma: Consensus from the Skin Cancer Prevention Working Group.

Melanoma Literature

Publication date: Mar 30, 2022 Prognostic assessment of cutaneous melanoma relies on historical, clinicopathological, and phenotypic risk factors according to American Joint Committee on Cancer(AJCC) and National Comprehensive Cancer Network ... Read more

March 31, 2022March 31, 2022

Parkinson's Disease and Acting Out Your Dreams (Ask the MD Podcast)

Parkinson's Disease Media

Publication date: Mar 30, 2022 We all dream when we sleep. Some don’t remember dreams. Others clearly recall what they did, how they felt, and who else was there. Still ... Read more

March 31, 2022March 31, 2022

Role of inflammasomes in HIV-1 infection and treatment.

Melanoma Literature

Publication date: Mar 24, 2022 Although combined antiretroviral therapy (cART) is effective in inhibiting human immunodeficiency virus type 1 (HIV-1) replication, it does not eradicate the virus because small amounts ... Read more