Fast raster-scan optoacoustic mesoscopy enables assessment of human melanoma microvasculature in vivo.

Publication date: May 19, 2022

Melanoma is associated with angiogenesis and vascular changes that may extend through the entire skin depth. Three-dimensional imaging of vascular characteristics in skin lesions could therefore allow diagnostic insights not available by conventional visual inspection. Raster-scan optoacoustic mesoscopy (RSOM) images microvasculature through the entire skin depth with resolutions of tens of micrometers; however, current RSOM implementations are too slow to overcome the strong breathing motions on the upper torso where melanoma lesions commonly occur. To enable high-resolution imaging of melanoma vasculature in humans, we accelerate RSOM scanning using an illumination scheme that is coaxial with a high-sensitivity ultrasound detector path, yielding 15 s single-breath-hold scans that minimize motion artifacts. We apply this Fast RSOM to image 10 melanomas and 10 benign nevi in vivo, showing marked differences between malignant and benign lesions, supporting the possibility to use biomarkers extracted from RSOM imaging of vasculature for lesion characterization to improve diagnostics.

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Concepts Keywords
Biomarkers Medical imaging
Malignant Melanoma
Microvasculature Multispectral optoacoustic tomography
Ultrasound Medicine
Vivo Nevus
Photoacoustic imaging


Type Source Name
disease MESH growth
disease MESH metastases
drug DRUGBANK Bismuth subgallate
drug DRUGBANK Tricyclazole
disease MESH excision margins
disease MESH employment
disease MESH histopathology
disease MESH aging
drug DRUGBANK Honey
disease MESH separation
disease MESH skin diseases
drug DRUGBANK Saquinavir
disease MESH melanocytic nevus
drug DRUGBANK Stavudine
drug DRUGBANK Pentaerythritol tetranitrate
disease MESH dysplastic nevus
drug DRUGBANK Cysteamine
drug DRUGBANK Albendazole
disease MESH noma
disease MESH vascular density
disease MESH psoriasis
drug DRUGBANK Sulodexide
drug DRUGBANK Trestolone
disease MESH diagnosis
disease MESH malignancies
drug DRUGBANK Coenzyme M
disease MESH Allergy
disease MESH nevi
pathway KEGG Melanoma
disease MESH melanoma

Original Article

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