Comparison of self-reported symptoms in COVID-19 patients who had or had not previously received COVID-19 mRNA vaccination.

Publication date: Aug 01, 2023

Although mRNA coronavirus disease 2019 (COVID-19) vaccines have been reported for high effectiveness against symptoms, it remains unclear whether post-vaccination infections are less symptomatic than infections in vaccine-naive individuals. We included patients with COVID-19 diagnosed by polymerase chain reaction tests during Japan’s alpha and delta variant epidemics. COVID-19 symptoms at approximately 4 weeks were compared based on COVID-19 vaccination status. In total, 398 cases (372 symptomatic and 26 asymptomatic; 286 unvaccinated, 66 vaccinated with one dose, and 46 with two doses) were analyzed. The most common symptoms were fever (78. 4%), fatigue (78. 4%), cough (74. 4%), loss of taste or smell (62. 8%), and headache (59. 8%). Post-vaccination infections were significantly less likely to be symptomatic. Possible confounder-adjusted odds ratios of two vaccine doses against fatigue, dry eyes and mouth, insomnia, fever, shortness of breath, unusual muscle pains, and loss of taste or smell were 0. 18 (95% confidence interval [CI]: 0. 09-0. 38), 0. 22 (95% CI: 0. 08-0. 59), 0. 33 (95% CI: 0. 14-0. 80), 0. 31 (95% CI: 0. 15-0. 63), 0. 36 (95% CI: 0. 16-0. 76), 0. 40 (95% CI: 0. 19-0. 82), and 0. 44 (95% CI: 0. 22-0. 87), respectively. Post-vaccination infections after two mRNA COVID-19 vaccine doses show milder and fewer symptoms than infections in unvaccinated patients, highlighting the effectiveness of vaccination.

Concepts Keywords
4weeks Coronavirus disease 2019 (COVID-19)
Coronavirus post-vaccination infection
Covid symptom
Dry vaccine


Type Source Name
disease MESH COVID-19
disease VO vaccination
disease VO effectiveness
disease MESH infections
disease VO vaccine
disease VO unvaccinated
disease VO vaccinated
disease VO dose
disease MESH dry eyes
disease VO mouth
disease MESH insomnia
disease VO COVID-19 vaccine
disease IDO infection
disease VO Severe acute respiratory syndrome coronavirus 2
disease IDO symptom

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