Publication date: Jun 26, 2023
Background: Adverse Childhood Experiences (ACEs) and Negative Life Events (NLEs) may activate immune-inflammatory pathways, which play a role in the onset of Major Depressive Disorder and its severe phenotype Major Dysmood disorder (MDMD). Objectives: To assess if elevated ACEs and NLEs in first episode (FE)-MDMD predict activation of the immune-inflammatory response system (IRS), chemokines, and growth factors that participate in the pathophysiology of MDMD. Methods: This research assessed the effects of ACEs and NLEs on forty-eight cytokines/chemokines/growth factors, in 71 FE-MDMD patients and forty heathy controls. Results: ACEs are highly significantly associated with the classical M1 macrophage, T helper (Th)-1, Th-1 polarization, IRS, and neurotoxicity immune profiles, and not with the alternative M2, and Th-2 immune profiles. There are highly significant correlations between ACEs and NLEs and different cytokines/chemokines/growth factors, especially with interleukin (IL)-16, CCL27, stem cell growth factor, and platelet-derived growth factor. Partial Least Squares analysis showed that 62.3% of the variance in the depression phenome (based on severity of depression, anxiety and suicidal behaviors) was explained by the regression on IL-4 (p=0.001, inversely), the sum of ACEs + NLEs (p
| Concepts | Keywords |
|---|---|
| Depressive | Aces |
| Faculty | Adverse |
| Irs | Chemokines |
| Seoul | Childhood |
| Depression | |
| Experiences | |
| Factor | |
| Factors | |
| Growth | |
| Immune | |
| Major | |
| Mdmd | |
| Nles | |
| Preprint |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Adverse childhood experiences |
| disease | MESH | Major Depressive Disorder |
| drug | DRUGBANK | Binetrakin |
| disease | MESH | Cognitive Impairment |
| disease | MESH | Dementia |
| drug | DRUGBANK | Coenzyme M |