Oral manifestations associated with Novel Coronavirus Disease – 2019 (COVID-19): A questionnaire based hypothetical study.

Publication date: May 11, 2023

Background: Since the Coronavirus disease 2019 (COVID-19) outbreak in 2019, the virus has evolved drastically, presenting with sets of mutations that influence its properties, including transmissibility and antigenicity. The oral mucosa is postulated as probable portal entry and several oral manifestations have been identified, which places dental professionals in a position to recognize probable COVID-19 patients depending on oral signs and symptoms in the initial phases of the disease itself. As co-existing with COVID-19 seems to be a new reality, greater understanding is required regarding early oral signs and symptoms which can be predictors for timely intervention and prevention of complications in COVID-19 patients. The objective of the study is to identify the distinguishing oral signs and symptoms among COVID-19 patients and to establish possible correlation between severity of COVID-19 infection and oral symptoms. Methods: This study recruited 179 ambulatory, non-hospitalized COVID-19 patients from the Kingdom of Saudi Arabia’s Eastern Province’s designated hotels for COVID-19 and home isolated patients from the same region using a convenience sample method. Data was collected by qualified and experienced investigators, including two physicians and three dentists, using a validated comprehensive questionnaire through telephonic interviews with the participants. The X was used to assess the categorical variables, and odd’s ratio was calculated to determine the strength of the association between general symptoms and oral manifestations. Results: Oral and nasopharyngeal lesions or conditions like loss of smell and taste, xerostomia, sore throat, and burning sensation were predictors of COVID-19-related systemic symptoms such as cough, fatigue, fever, and nasal congestion were identified to be statistically significant (p

Open Access PDF

Concepts Keywords
Coronavirus ageusia
Dentists anosmia
F1000res COVID-19
Mucosa COVID-19
Timely Humans
Olfaction Disorders
oral symptoms
Surveys and Questionnaires


Type Source Name
pathway KEGG Coronavirus disease
disease MESH COVID-19
disease IDO intervention
disease MESH complications
disease MESH infection
disease MESH xerostomia
disease MESH sore throat
drug DRUGBANK Amber
pathway REACTOME Reproduction
disease MESH Olfaction Disorders

Original Article

(Visited 1 times, 1 visits today)

Leave a Comment

Your email address will not be published. Required fields are marked *