Impact of imprinted immunity induced by mRNA vaccination in an experimental animal model.

Publication date: Jun 27, 2023

The emergence of SARS-CoV-2 Omicron variants has led to concerns that ancestral SARS-CoV-2-based vaccines may not be effective against newly emerging Omicron subvariants. The concept of “imprinted immunity” suggests that individuals vaccinated with ancestral virus-based vaccines may not develop effective immunity against newly emerging Omicron subvariants, such as BQ. 1.1 and XBB. 1. Here, we investigated this possibility using hamsters. While natural infection induced effective antiviral immunity, breakthrough infections in hamsters with BQ. 1.1 and XBB. 1 Omicron subvariants after receiving the 3-dose mRNA-LNP vaccine resulted in only faintly induced humoral immunity, supporting the possibility of imprinted immunity.

Concepts Keywords
Ancestral imprinted immunity
Antiviral mRNA vaccine
Hamsters Omicron
Mrna SARS-CoV-2


Type Source Name
disease VO vaccination
disease VO effective
disease VO vaccinated
disease MESH infection
disease MESH breakthrough infections
disease VO dose
disease VO vaccine

Original Article

(Visited 1 times, 1 visits today)

Leave a Comment

Your email address will not be published. Required fields are marked *