Publication date: Jul 08, 2023
We examined the progression of extrapyramidal symptoms and signs in autopsy-confirmed dementia with Lewy bodies (DLB), Parkinson’s disease dementia (PDD), and Alzheimer’s disease dementia (AD). Longitudinal data were obtained from Arizona Study of Aging and Neurodegenerative Disease, with PDD (n = 98), AD (n = 47) and DLB (n = 48) further sub-grouped as with or without parkinsonism (DLB+ and DLB-). Within-group Unified Parkinson’s Disease Rating Scale (UPDRS) -II and UPDRS-III trajectories were analyzed using non-linear mixed effects models. In DLB, 65. 6% had parkinsonism. Baseline UPDRS-II and III scores (off-stage) were highest (P
| Concepts | Keywords |
|---|---|
| Alzheimers | motor trajectories |
| Arizona | parkinsonism |
| Autopsy | |
| Extrapyramidal | |
| Models |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | dementia |
| disease | MESH | Parkinson disease |
| pathway | KEGG | Parkinson disease |
| disease | MESH | Neurodegenerative Disease |
| disease | MESH | parkinsonism |
Original Article
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