Longitudinal motor decline in dementia with Lewy bodies, Parkinson disease dementia, and Alzheimer’s dementia in a community autopsy cohort.

Publication date: Jul 08, 2023

We examined the progression of extrapyramidal symptoms and signs in autopsy-confirmed dementia with Lewy bodies (DLB), Parkinson’s disease dementia (PDD), and Alzheimer’s disease dementia (AD). Longitudinal data were obtained from Arizona Study of Aging and Neurodegenerative Disease, with PDD (n = 98), AD (n = 47) and DLB (n = 48) further sub-grouped as with or without parkinsonism (DLB+ and DLB-). Within-group Unified Parkinson’s Disease Rating Scale (UPDRS) -II and UPDRS-III trajectories were analyzed using non-linear mixed effects models. In DLB, 65. 6% had parkinsonism. Baseline UPDRS-II and III scores (off-stage) were highest (P

Concepts Keywords
Alzheimers motor trajectories
Arizona parkinsonism


Type Source Name
disease MESH dementia
disease MESH Parkinson disease
pathway KEGG Parkinson disease
disease MESH Neurodegenerative Disease
disease MESH parkinsonism

Original Article

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