Associations between an obesity-related dietary pattern and incidence of overall and site-specific cancers: a prospective cohort study.

Publication date: Jul 10, 2023

A dietary pattern (DP) may impact on cancer incidence more strongly than individual foods, but this association remains uncertain. Here, we aimed to broadly explore the associations of an obesity-related DP with overall and 19 site-specific cancers. This study included 114,289 cancer-free participants with at least two dietary assessments. A total of 210 food items were classified into 47 food groups, and the mean amount of each food group was used in reduced-rank regression to derive the obesity-related DP. Cox regressions were conducted to explore the associations of the obesity-related DP with overall and 19 site-specific cancers. The parallel mediation model was constructed to quantify the mediating roles of potential mediators. During a median follow-up period of 9. 4 years, 10,145 (8. 9%) incident cancer cases were documented. The derived-DP was characterized by a higher intake of beer and cider, processed meat, high sugar beverages, red meat, and artificial sweetener, and a lower intake of fresh vegetables, olive oil, tea, and high fiber breakfast cereals. Observational analysis showed that a higher obesity-related DP Z-score was linearly associated with an increased risk of overall cancer (adjusted hazard ratio (HR) = 1. 02, 95% CI: 1. 01, 1. 04 per 1-SD increase, corrected P 

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Concepts Keywords
Breakfast Cancer risk
Cancer Cohort study
Obesity Dietary pattern
Tea Reduced-rank regression


Type Source Name
disease MESH obesity
disease MESH cancers
drug DRUGBANK Olive oil
pathway REACTOME Reproduction
disease MESH malignant melanoma
disease MESH weight gain
pathway KEGG Apoptosis
disease MESH oxidative damage
disease MESH metabolic syndrome
pathway KEGG Melanoma
disease MESH skin cancer
disease MESH death
disease MESH non Hodgkin lymphoma
disease MESH multiple myeloma
disease MESH leukemia
drug DRUGBANK Etoperidone
disease MESH morbidities
drug DRUGBANK Methionine
disease MESH hypertension
disease MESH hypercholesterolemia
disease MESH cardiovascular diseases
disease MESH heart attack
disease MESH stroke
drug DRUGBANK Esomeprazole
disease MESH education level
disease MESH endometrium cancers
disease MESH breast cancer
pathway KEGG Breast cancer
drug DRUGBANK Dextrose unspecified form
drug DRUGBANK Ranitidine
disease MESH causality
drug DRUGBANK Cholesterol
disease MESH bladder cancers
disease MESH thyroid cancers
drug DRUGBANK Trestolone
disease MESH Western diet
disease MESH prostate cancers
disease MESH carcinogenesis
disease MESH chronic diseases
disease MESH inflammation
drug DRUGBANK Iron
drug DRUGBANK Nitrite
drug DRUGBANK Ethanol
drug DRUGBANK Nitrate
disease MESH adenocarcinoma
disease MESH noma
disease MESH missed diagnoses
disease MESH dyslipidemia
drug DRUGBANK Coenzyme M
drug DRUGBANK Platelet Activating Factor
drug DRUGBANK Carboxyamidotriazole
disease MESH colorectal cancer
pathway KEGG Colorectal cancer
disease MESH underweight
disease MESH overweight
drug DRUGBANK Stavudine
drug DRUGBANK Tretamine
drug DRUGBANK Hexachlorophene
disease MESH coronary heart disease
disease MESH lifestyle factors
drug DRUGBANK Pidolic Acid
drug DRUGBANK Fenamole
disease MESH carcinoma
drug DRUGBANK Guanosine
drug DRUGBANK Gold
disease MESH gastric cancer
pathway KEGG Gastric cancer
drug DRUGBANK (S)-Des-Me-Ampa

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