Neuropsychological domains and fitness to drive in mild cognitive impairment or Alzheimer’s disease.

Publication date: Jul 07, 2023

Cognitive deficits associated with mild cognitive impairment (MCI) or Alzheimer’s disease (AD) can impact driving. This integrative review investigated which cognitive domains were associated with poor driving performance or unfitness to drive in studies with outcomes measured in simulator or on-road driving in patients with MCI or AD. The review was conducted by searching for articles published between 2001 and 2020 in the MEDLINE (via PubMed), EMBASE, and SCOPUS databases. Studies addressing patients with other dementias (e. g., vascular or mixed dementia, Lewy body dementia, Parkinson’s disease) were excluded. Of 404 articles initially selected, 17 met the eligibility criteria for this review. Based on the findings of this integrative review, attentional capacity, processing speed, executive functions and visuospatial skills were the functions whose declines were most frequently reported in a context of unsafe driving by older adults with MCI or AD. Reports were remarkably heterogeneous in methodological aspects whereas quite limited in cross-cultural coverage and in sample recruited, what prompts for further trials in the field.

Concepts Keywords
Alzheimer Aged
Databases Alzheimer disease
Driving Automobile driving
Mild Cognitive dysfunction
Neuropsychological Neuropsychological tests


Type Source Name
disease MESH mild cognitive impairment
disease MESH dementias
drug DRUGBANK Methionine
disease MESH Alzheimer disease
pathway KEGG Alzheimer disease

Original Article

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