Publication date: Jul 10, 2023
This is a randomized, double-blind, placebo-controlled Phase II clinical study to evaluate the efficacy and safety of continuous oral administration of HS-10353 in Chinese adults with depression. HS-10353 is a new generation of GABAA receptor isomeric modulator developed by our company, which can correct the dysfunction of GABAA receptor function and restore the balance between GABA receptor and NMDA receptor. Oral administration of HS-10353 at night for 14 days is expected to reduce clinical symptoms in patients with depression. As an oral preparation of allopregnenolone analogitics, it has good bioavailability, rapid onset and high safety, and has broad clinical application prospects, which is expected to better meet the treatment needs of clinical depression in China in the future.
| Concepts | Keywords |
|---|---|
| Carbamazepine | Blood |
| Chinese | Clinical |
| Depressive | Current |
| Grapefruit | Depressive |
| Disorder | |
| Disorders | |
| Episode | |
| History | |
| Hs | |
| Mdd | |
| Participants | |
| Phase | |
| Screening | |
| Subjects | |
| Treatment |
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Tropicamide |
| drug | DRUGBANK | gamma-Aminobutyric acid |
| drug | DRUGBANK | Isoxaflutole |
| disease | MESH | Major Depressive Disorder |
| drug | DRUGBANK | Methionine |
| disease | MESH | Mental Disorders |
| disease | MESH | depressive disorder |
| disease | MESH | abnormalities |
| drug | DRUGBANK | Chorionic Gonadotropin (Human) |
| disease | MESH | schizophrenia |
| disease | MESH | psychosis |
| disease | MESH | dissociation |
| disease | MESH | anorexia |
| disease | MESH | bulimia nervosa |
| disease | MESH | personality disorders |
| disease | MESH | Suicide |
| disease | MESH | seizures |
| disease | MESH | febrile convulsions |
| disease | MESH | allergies |
| drug | DRUGBANK | Ethanol |
| disease | MESH | drug dependence |
| drug | DRUGBANK | Nicotine |
| drug | DRUGBANK | Caffeine |
| drug | DRUGBANK | Rifampicin |
| drug | DRUGBANK | Carbamazepine |
| drug | DRUGBANK | Ritonavir |
| drug | DRUGBANK | Enzalutamide |
| drug | DRUGBANK | Nevirapine |
| drug | DRUGBANK | Phenytoin |
| drug | DRUGBANK | Phenobarbital |
| drug | DRUGBANK | Tilmicosin |