Effectiveness of inactivated influenza and COVID-19 vaccines in hospitalized children in 2022/23 season in Japan – The first season of co-circulation of influenza and COVID-19.

Publication date: Jun 30, 2023

We have analyzed the inactivated vaccine effectiveness (VE)for preventing influenza hospitalization by test-negative design in the 2022/23 season. This is the first season of co-circulation of influenza and COVID-19, and a unique period because all inpatients received COVID-19 screening. Among 536 children hospitalized with fever, none were positive for both influenza and SARS-CoV-2. The adjusted VE for preventing influenza A for all children, the 6-12-year-old group, and those with underlying diseases was 34 % (95 %CI, -16 %-61 %, n = 474), 76 % (95 % CI, 21 %-92 %, n = 81), and 92 % (95 % CI, 30 %-99 %, n = 86), respectively. Only 1 out of 35 hospitalized cases with COVID-19, and 42 out of 429 controls, had been immunized with COVID-19 vaccine. This is the first report showing influenza VE by age group in children in this limited season. We still recommend the inactivated influenza vaccine for children based on the significant VE in subgroup analysis.

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Concepts Keywords
Inactivated Children
Inpatients COVID-19
Japan Influenza
Vaccines Test-negative design
Vaccine effectiveness


Type Source Name
disease VO effectiveness
disease MESH influenza
disease MESH COVID-19
disease VO vaccine effectiveness
pathway KEGG Influenza A
disease VO immunized
disease VO COVID-19 vaccine
disease VO report
disease VO inactivated influenza vaccine
disease VO vaccine
drug DRUGBANK Coenzyme M
drug DRUGBANK Abacavir
disease MESH Infectious Diseases
disease MESH Infection
disease VO organization
drug DRUGBANK (S)-Des-Me-Ampa
disease MESH Allergy
disease IDO history
disease VO effective
pathway REACTOME Influenza Infection
drug DRUGBANK Trestolone
disease VO time
disease VO dose
disease VO vaccinated
disease VO unvaccinated
disease MESH comorbidity
disease VO USA
disease VO vaccination
disease MESH epilepsy
disease MESH asthma
pathway KEGG Asthma
disease MESH seizures
disease MESH respiratory diseases

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