Updated mortality and causes of death in 2020-2021 in people living with HIV: a multicenter study in France.

Publication date: Jul 10, 2023

To assess updated mortality and causes of death in people living with HIV (PLWH) in France. We analyzed all deaths in PLWH followed up between 01/01/2020 and 31/12/2021 in 11 hospitals in the Paris region. We described the characteristics and causes of death among deceased PLWH, and evaluated the incidence of mortality and associated risk factors using a multivariate logistic regression. Of the 12942 patients followed in 2020-2021, 202 deaths occurred. Mean annual incidence of death (95% confidence interval [CI]) was 7. 8 per 1 000 PLWH (6. 3-9. 5). Forty-seven patients (23%) died from non-AIDS non-viral hepatitis (NANH)-related malignancies, 38 (19%) from non-AIDS infections (including 21 cases of COVID-19), 20 (10%) from AIDS, 19 (9%) from cardiovascular diseases (CVD), 17 (8. 4%) from other causes, six (3%) from liver diseases and five (2. 5%) from suicides/violent deaths. The cause of death was unknown in 50 (24. 7%) patients. Risks factors for death were age (adjusted Odds Ratio (aOR) 1. 93; 1. 66-2. 25 by additional decade), AIDS history (2. 23; 1. 61-3. 09), low CD4 (1. 95; 1. 36-2. 78 for 200-500/μL and 5. 76; 3. 65-9. 08 for ≤ 200/μL versus > 500/μL), and viral load > 50 copies/mL (2. 03; 1. 33-3. 08), both at last visit. NANH malignancies remained in 2020-2021 the first cause of death. COVID-19 accounted for more than half of the mortality related to non-AIDS infections over the period. Aging, AIDS history, and a poorer viro-immunological control were associated with death.

Concepts Keywords
50copies Aids
Death Death
Hiv Deaths
Paris Factors


Type Source Name
disease MESH causes of death
disease MESH death
disease MESH AIDS
disease MESH hepatitis
disease MESH malignancies
disease MESH infections
disease MESH COVID-19
disease MESH cardiovascular diseases
disease MESH causes
disease MESH liver diseases
disease MESH suicides
disease IDO history

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