Publication date: Jul 11, 2023
When we examined cells taken from the fluid within a blister in human skin, we found cells that look remarkably similar to zebrafish melanocyte stem cells. The involvement of multiple stem cells likely enables regeneration to nimbly adjust to different types of injuries. From fish to peopleOur findings from zebrafish are likely relevant to human skin. Since melanocyte stem cells in zebrafish are externally visible, we tracked these cells in real time to see how they divided and matured. Our zebrafish studies indicate that multiple different stem cells in skin, and potentially other tissues, can together reconstruct one particular cell type after injury. Surprisingly, we identified two types of stem cells that each took a different route to make new melanocytes. Craig Ceol, CC BY-NDTo study melanocyte regeneration, we removed these cells from zebrafish and followed their process of regrowth. The other type of stem cell divided to create two types of daughter cells.