Role of neuroinflammation in neurodegeneration development.

Publication date: Jul 12, 2023

Studies in neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and Amyotrophic lateral sclerosis, Huntington’s disease, and so on, have suggested that inflammation is not only a result of neurodegeneration but also a crucial player in this process. Protein aggregates which are very common pathological phenomenon in neurodegeneration can induce neuroinflammation which further aggravates protein aggregation and neurodegeneration. Actually, inflammation even happens earlier than protein aggregation. Neuroinflammation induced by genetic variations in CNS cells or by peripheral immune cells may induce protein deposition in some susceptible population. Numerous signaling pathways and a range of CNS cells have been suggested to be involved in the pathogenesis of neurodegeneration, although they are still far from being completely understood. Due to the limited success of traditional treatment methods, blocking or enhancing inflammatory signaling pathways involved in neurodegeneration are considered to be promising strategies for the therapy of neurodegenerative diseases, and many of them have got exciting results in animal models or clinical trials. Some of them, although very few, have been approved by FDA for clinical usage. Here we comprehensively review the factors affecting neuroinflammation and the major inflammatory signaling pathways involved in the pathogenicity of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and Amyotrophic lateral sclerosis. We also summarize the current strategies, both in animal models and in the clinic, for the treatment of neurodegenerative diseases.

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Concepts Keywords
Alzheimer Alzheimer
Common Amyotrophic
Fda Disease
Genetic Diseases
Neurodegenerative Including


Type Source Name
disease MESH neurodegenerative diseases
disease MESH neuroinflammation
drug DRUGBANK Spinosad
disease MESH pathogenesis
disease MESH inflammation
pathway KEGG Amyotrophic lateral sclerosis
disease MESH Amyotrophic lateral sclerosis
pathway REACTOME Neurodegenerative Diseases
disease MESH neurological disorders
disease MESH frontotemporal dementia
disease MESH neurofibrillary tangles
drug DRUGBANK Thiocolchicoside
disease MESH senile plaques
drug DRUGBANK Medical air
drug DRUGBANK Coenzyme M
disease MESH infection
disease MESH dysbiosis
disease MESH cognitive impairment
drug DRUGBANK Oxygen
drug DRUGBANK Nitric Oxide
disease MESH death
drug DRUGBANK Iron
drug DRUGBANK Adenosine
drug DRUGBANK Uric Acid
disease MESH PRRs
disease MESH dissociation
drug DRUGBANK Dopamine
drug DRUGBANK Albendazole
disease MESH oxidative stress
disease MESH immune disease
disease MESH multiple sclerosis
disease MESH fatal outcome
disease MESH autoimmune diseases
disease MESH dementia
disease MESH bacterial infections
disease MESH herpes simplex
disease MESH COVID 19 pandemic
disease MESH parkinsonism
disease MESH chronic diseases
disease MESH obesity
disease MESH atherosclerosis
drug DRUGBANK Dextrose unspecified form
disease MESH loneliness
disease MESH comorbidity
drug DRUGBANK Dinoprostone
drug DRUGBANK Melatonin
disease MESH brain inflammation
disease MESH ischemia
drug DRUGBANK Trestolone
pathway KEGG Apoptosis
disease MESH tauopathy
disease MESH amyloidosis
drug DRUGBANK L-Tyrosine
drug DRUGBANK L-Leucine
drug DRUGBANK Trihexyphenidyl
drug DRUGBANK Profenamine
disease MESH GBA deficiency
pathway KEGG Mitophagy
drug DRUGBANK Pentaerythritol tetranitrate
drug DRUGBANK N-acetylsulfanilyl chloride
pathway KEGG Autophagy
disease MESH synucleinopathies
drug DRUGBANK Cholesterol
disease MESH shock
disease MESH haploinsufficiency
drug DRUGBANK Estradiol
drug DRUGBANK Anakinra
drug DRUGBANK Canakinumab
drug DRUGBANK Rilonacept
drug DRUGBANK Uridine 5′-triphosphate
drug DRUGBANK Uridine
drug DRUGBANK Adenosine phosphate
disease MESH astrogliosis
pathway KEGG Lysosome
drug DRUGBANK Nicotinamide
drug DRUGBANK Omega-3 fatty acids
drug DRUGBANK Arachidonic Acid
drug DRUGBANK Doconexent
drug DRUGBANK Icosapent
drug DRUGBANK Resolvin E1
drug DRUGBANK Prostaglandin D2
drug DRUGBANK L-Arginine
drug DRUGBANK L-Citrulline
disease MESH tumor
disease MESH pleurisy
disease MESH premature mortality
disease MESH histocompatibility
pathway KEGG Tight junction
drug DRUGBANK Fluorescein
disease MESH leukemia
disease MESH meningoencephalitis
drug DRUGBANK Aducanumab
drug DRUGBANK Huperzine B
drug DRUGBANK Ibuprofen
drug DRUGBANK Cromoglicic acid
drug DRUGBANK Minocycline
drug DRUGBANK Tetracycline
drug DRUGBANK Metformin
disease MESH diabetes mellitus
drug DRUGBANK Liraglutide
drug DRUGBANK Pioglitazone
drug DRUGBANK Daratumumab
drug DRUGBANK Naloxone
drug DRUGBANK Exenatide
drug DRUGBANK Semaglutide
drug DRUGBANK Sargramostim
drug DRUGBANK Bapineuzumab
drug DRUGBANK Solanezumab
drug DRUGBANK Crenezumab
drug DRUGBANK Gantenerumab
drug DRUGBANK Etanercept
drug DRUGBANK Lenalidomide
drug DRUGBANK Baricitinib
drug DRUGBANK HE3286
drug DRUGBANK Dexamethasone
drug DRUGBANK Masitinib
drug DRUGBANK Celecoxib
drug DRUGBANK Butylphthalide
drug DRUGBANK Ibudilast
drug DRUGBANK Edaravone
drug DRUGBANK Serine
drug DRUGBANK L-Threonine
drug DRUGBANK Pridopidine
drug DRUGBANK Fingolimod
drug DRUGBANK Tocilizumab
drug DRUGBANK Mesenchymal Stem Cells
disease MESH senile dementia
drug DRUGBANK Glycine
disease MESH AIDS
drug DRUGBANK (S)-Des-Me-Ampa
disease MESH Complement deficiency
drug DRUGBANK Guanosine
disease MESH Parkinson disease
pathway KEGG Parkinson disease
drug DRUGBANK Rifampicin
disease MESH frontotemporal lobar degeneration
disease MESH autoimmunity
disease MESH neuron degeneration
disease MESH insulin resistance
pathway KEGG Insulin resistance
drug DRUGBANK Palmitic Acid
drug DRUGBANK Oleic Acid
disease MESH cerebral amyloid angiopathy
disease MESH immune tolerance
drug DRUGBANK Amino acids
disease MESH cerebral edema
pathway KEGG Alzheimer disease
pathway KEGG Metabolic pathways
disease MESH repression
drug DRUGBANK L-Phenylalanine
disease MESH stroke
drug DRUGBANK Formaldehyde
drug DRUGBANK Muplestim
disease MESH defects
drug DRUGBANK Triptolide
drug DRUGBANK Tretamine
disease MESH central nervous system infections
disease MESH seizure
drug DRUGBANK D-Alanine
disease MESH tumor immune evasion
disease MESH genome instability
disease MESH brain disorders
disease MESH vascular dementia
disease MESH MPTP induced Parkinsonism
drug DRUGBANK Medroxyprogesterone acetate
drug DRUGBANK Tretinoin
disease MESH pulmonary hypertension
drug DRUGBANK Sulfasalazine
drug DRUGBANK Ranitidine

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