Booster vaccinations and Omicron: the effects on SARS-CoV-2 antibodies in Dutch blood donors.

Publication date: Jul 12, 2023

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) booster vaccination campaign and the emergence of SARS-CoV-2 Omicron variants impact the prevalence and levels of SARS-CoV-2 antibodies in the Netherlands. In this study we determined antibody levels across age groups, the impact of Omicron variant infections, and the effect of booster vaccinations on antibody levels. In September and December 2021 and in February 2022, over 2000 Dutch blood donors were tested for presence of SARS-CoV-2 antibodies. Donations were selected based on age, sex, and region of residence, to provide an optimal coverage and representation of the Dutch population. Levels of vaccination-induced spike antibodies decreased over time in all age groups. Donors vaccinated with Janssen or AstraZeneca had significantly lower antibody levels than donors vaccinated with Pfizer or Moderna vaccine. Boostering with an mRNA vaccine elevated antibody levels in all age-groups irrespective of the initial vaccine. In donors aged 

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Concepts Keywords
Astrazeneca Antibodies
Coronavirus Antibody waning
Dutch Blood donor
Severe Infection


Type Source Name
disease IDO blood
disease VO Severe acute respiratory syndrome coronavirus 2
disease VO vaccination
disease MESH infections
disease VO population
disease VO time
disease VO vaccinated
disease VO vaccine
pathway REACTOME Reproduction
disease MESH Infectious Diseases
drug DRUGBANK Etoperidone
disease IDO infection
disease IDO pathogen
disease MESH COVID 19
disease IDO infectivity
disease VO dose
disease VO USA
disease VO organization
drug DRUGBANK Cysteamine
disease IDO assay
disease VO age
disease MESH breakthrough infections
disease VO antibody titer
disease VO effectiveness
disease MESH re infection
disease IDO process
disease IDO symptom
disease MESH Pneumonia
drug DRUGBANK Methyldopa
disease VO vaccine effectiveness

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