Publication date: Jul 12, 2023
The wave of coronavirus disease 2019 (COVID-19) with Omicron variant reached its first peak in Beijing, China in December 2022. We delineated characteristics and factors associated with adverse outcome of patients with plasma cell dyscrasias (PCDs) and COVID-19 during the first month of the wave. A total of 104 patients with a median age of 65 years were included in the study, with multiple myeloma (74%, n=77) and primary Immunoglobulin light chain amyloidosis (16. 3%, n=17) being the two most common disease. Overall, severe or critical COVID-19 was developed in 18 (17. 3%) patients, with a total all-cause mortality rate of 4. 8% (n=5). The vaccination coverage was 41% and 48. 1%, before and during the upsurge of Omicron, respectively, calling for the improvement of vaccination in PCD patients. Multivariable analysis revealed that age was the only independent risk factors (OR=1. 14, 95% CI: 1. 06-1. 26, p = 0. 002) associated with the development of severe or critical disease. Among patients with severe or critical group, low levels of albumin (HR=18. 29; 95% CI: 1. 82-183. 44, p = 0. 013) and high levels of lactic dehydrogenase (LDH) (HR=0. 08; 95% CI: 0. 01-0. 65, p = 0. 018) were associated with longer time to negative conversion of COVID-19.
|Amyloidosis||Coronavirus disease 2019|
|Coronavirus||Plasma cell dyscrasias|
|disease||MESH||plasma cell dyscrasias|
|disease||MESH||Immunoglobulin light chain amyloidosis|