Characteristics and outcomes of COVID-19 in patients with plasma cell dyscrasias during the first Omicron wave in Beijing since December 2022: a retrospective study at a National Clinical Research Center for Hematologic Disease.

Publication date: Jul 12, 2023

The wave of coronavirus disease 2019 (COVID-19) with Omicron variant reached its first peak in Beijing, China in December 2022. We delineated characteristics and factors associated with adverse outcome of patients with plasma cell dyscrasias (PCDs) and COVID-19 during the first month of the wave. A total of 104 patients with a median age of 65 years were included in the study, with multiple myeloma (74%, n=77) and primary Immunoglobulin light chain amyloidosis (16. 3%, n=17) being the two most common disease. Overall, severe or critical COVID-19 was developed in 18 (17. 3%) patients, with a total all-cause mortality rate of 4. 8% (n=5). The vaccination coverage was 41% and 48. 1%, before and during the upsurge of Omicron, respectively, calling for the improvement of vaccination in PCD patients. Multivariable analysis revealed that age was the only independent risk factors (OR=1. 14, 95% CI: 1. 06-1. 26, p = 0. 002) associated with the development of severe or critical disease. Among patients with severe or critical group, low levels of albumin (HR=18. 29; 95% CI: 1. 82-183. 44, p = 0. 013) and high levels of lactic dehydrogenase (LDH) (HR=0. 08; 95% CI: 0. 01-0. 65, p = 0. 018) were associated with longer time to negative conversion of COVID-19.

Concepts Keywords
Amyloidosis Coronavirus disease 2019
Beijing Omicron
Coronavirus Plasma cell dyscrasias


Type Source Name
disease MESH COVID-19
disease MESH plasma cell dyscrasias
disease MESH Hematologic Disease
disease MESH multiple myeloma
disease MESH Immunoglobulin light chain amyloidosis
disease VO vaccination coverage
disease VO vaccination
disease VO time

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