Depression severity partially mediates the association between thyroid function and psychotic symptoms in first-episode, drug-naive major depressive disorder patients with comorbid anxiety at different ages of onset.

Publication date: Jul 10, 2023

Anxiety and psychotic symptoms are common in patients with major depressive disorder (MDD), with a strong association with thyroid function. Age of onset contributes to the heterogeneity of MDD patients. This study aimed to assess the prevalence of psychotic symptoms in MDD patients with comorbid anxiety and to explore the relationship between thyroid function and psychotic symptoms by ages of onset. A total of 894 first-episode, drug-nacEFve Chinese Han MDD patients with comorbid anxiety were recruited. Thyroid function and psychometric measures including Hamilton Anxiety Scale, Hamilton Depression Scale, and Positive and Negative Syndrome Scale were evaluated. Patients were divided into early adulthood onset (EAO,

Concepts Keywords
Chinese Age of onset
Hamilton Anxiety
Psychometric Major depressive disorder
Recent Psychotic symptoms
Thyroid Thyroid function


Type Source Name
disease MESH major depressive disorder
disease MESH Syndrome

Original Article

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