Viral manipulation of cell polarity signalling.

Publication date: Jul 10, 2023

Cell polarity refers to the asymmetric distribution of biomacromolecules that enable the correct orientation of a cell in a particular direction. It is thus an essential component for appropriate tissue development and function. Viral infections can lead to dysregulation of polarity. This is associated with a poor prognosis due to viral interference with core cell polarity regulatory scaffolding proteins that often feature PDZ (PSD-95, DLG, and ZO-1) domains including Scrib, Dlg, Pals1, PatJ, Par3 and Par6. PDZ domains are also promiscuous, binding to several different partners through their C-terminal region which contain PDZ-binding motifs (PBM). Numerous viruses encode viral effector proteins that target cell polarity regulators for their benefit and include papillomaviruses, flaviviruses and coronaviruses. A better understanding of the mechanisms of action utilised by viral effector proteins to subvert host cell polarity sigalling will provide avenues for future therapeutic intervention, while at the same time enhance our understanding of cell polarity regulation and its role tissue homeostasis.

Concepts Keywords
Biophys Cell polarity
Homeostasis Crumbs
Numerous Par
Papillomaviruses PDZ domain
Pbm Scribble


Type Source Name
disease IDO cell
disease MESH Viral infections
disease VO Viruses
drug DRUGBANK Tropicamide
disease IDO intervention
disease VO time

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