Deterioration of Visual Acuity after Brachytherapy and Proton Therapy of Uveal Melanoma, and Methods of Counteracting This Complication Based on Recent Publications.

Publication date: Jun 12, 2023

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. The eyeball is the most common extracutaneous location of melanoma. UM is a huge threat to a patient’s life. It metastasizes distantly via blood vessels, but it can also spread locally and infiltrate extraocular structures. The treatment uses surgical methods, which include, among others, enucleation and conservative methods, such as brachytherapy (BT), proton therapy (PT), stereotactic radiotherapy (SRT), stereotactic radiosurgery (SRS), transpupillary thermotherapy (TTT) and photodynamic therapy. The key advantage of radiotherapy, which is currently used in most patients, is the preservation of the eyeball with the risk of metastasis and mortality comparable to that of enucleation. Unfortunately, radiotherapy very often leads to a significant deterioration in visual acuity (VA) as a result of radiation complications. This article is a review of the latest research on ruthenium-106 (Ru-106) brachytherapy, iodine-125 (I-125) brachytherapy and proton therapy of uveal melanoma that took into account the deterioration of eye function after therapy, and also the latest studies presenting the new concepts of modifications to the applied treatments in order to reduce radiation complications and maintain better visual acuity in treated patients.

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Concepts Keywords
Brachytherapy Adult
Latest Brachytherapy
Mortality brachytherapy
Photodynamic Humans
Iodine Radioisotopes
Iodine Radioisotopes
Proton Therapy
proton therapy
radiation complications
radiation therapy
Retrospective Studies
uveal melanoma
vision deterioration
Visual Acuity
visual acuity


Type Source Name
disease MESH Uveal Melanoma
disease MESH malignancy
disease MESH melanoma
pathway KEGG Melanoma
disease MESH metastasis
disease MESH complications
drug DRUGBANK Iodine
drug DRUGBANK Tropicamide

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