Publication date: Jul 13, 2023
In this assessment, participants completed a series of cognitive tasks to measure things like memory, decision speed, and attention span while an fMRI tracked their neuronal activity. The new research study led by Standford Medicine published on JAMA Network1 suggests that a certain “cognitive biotype” of depression may respond poorly to standard antidepressants. Both before and after the antidepressant treatment, the participants’ depressive symptoms were measured using two surveys (one administered by a clinician and the other self-reported) and a cognitive assessment. In this case, biotype refers to people who share similar neuronal patterns when it comes to learning and processing information and regulating mood. According to the American Psychological Association, a biotype refers to a group of individuals with a similar genetic makeup. A total of 712 participants completed the 8-week prescription. Hold on: What’s a biotype?
| Concepts | Keywords |
|---|---|
| Adults | Activity |
| Clinician | Antidepressants |
| Depressive | Biotype |
| Genetic | Brain |
| Cognitive | |
| Concentration | |
| Depression | |
| Memory | |
| Neuronal | |
| Participants | |
| Refers | |
| Respond | |
| Self | |
| Similar | |
| Symptoms |
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Venlafaxine |
| drug | DRUGBANK | Sertraline |
| drug | DRUGBANK | Escitalopram |
| disease | MESH | major depressive disorder |