Intensive exercise ameliorates motor and cognitive symptoms in experimental Parkinson’s disease restoring striatal synaptic plasticity.

Publication date: Jul 14, 2023

Intensive physical activity improves motor functions in patients with Parkinson’s disease (PD) at early stages. However, the mechanisms underlying the beneficial effects of exercise on PD-associated neuronal alterations have not been fully clarified yet. Here, we tested the hypothesis that an intensive treadmill training program rescues alterations in striatal plasticity and early motor and cognitive deficits in rats receiving an intrastriatal injection of alpha-synuclein (α-syn) preformed fibrils. Improved motor control and visuospatial learning in active animals were associated with a recovery of dendritic spine density alterations and a lasting rescue of a physiological corticostriatal long-term potentiation (LTP). Pharmacological analyses of LTP show that modulations of N-methyl-d-aspartate receptors bearing GluN2B subunits and tropomyosin receptor kinase B, the main brain-derived neurotrophic factor receptor, are involved in these beneficial effects. We demonstrate that intensive exercise training has effects on the early plastic alterations induced by α-syn aggregates and reduces the spread of toxic α-syn species to other vulnerable brain areas.

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Concepts Keywords
Early Alterations
Kinase Beneficial
Parkinson Cognitive
Therapy Early
Treadmill Exercise


Type Source Name
pathway KEGG Long-term potentiation
drug DRUGBANK Dopamine
pathway KEGG Peroxisome
drug DRUGBANK Phosphate ion
drug DRUGBANK Trestolone
drug DRUGBANK L-Tyrosine
drug DRUGBANK Proline
disease MESH death
drug DRUGBANK Sulpiride
drug DRUGBANK Magnesium
drug DRUGBANK Nevirapine
drug DRUGBANK Ifenprodil
drug DRUGBANK Esomeprazole
drug DRUGBANK Glutamic Acid
disease MESH dementia
drug DRUGBANK Adenosine
drug DRUGBANK Water
drug DRUGBANK Ketamine
drug DRUGBANK Xylazine
drug DRUGBANK Hexocyclium

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