Publication date: Jul 15, 2023

The sleep deprivation groups underwent one scan after a normal nights sleep, another after a sleepless night and a third after two nights of recovery sleep. This signal in people reporting mood improvement regardless of depression diagnosis is an important clue to understanding how sleep deprivation works, Wirz-Justice says. Sleep deprivation has disadvantages that include, well, going without sleep. Gehrman says that brain circuits that are responsive to sleep deprivation could represent candidate targets for transcranial magnetic stimulation or other kinds of stimulation. The other is the anterior cingulate cortex, which studies have connected to depression and to the benefits of sleep deprivation. In 1818 Johann Christian August Heinroth, considered to have been the first professor of psychiatry at a university, suggested that sleep deprivation might alleviate melancholia, or depression. The 16 control participants without depression underwent three scans, too, but got regular sleep.

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