The neonatal risk factors associated with attention-deficit/ hyperactivity disorder: an umbrella review.

Publication date: Jul 14, 2023

Attention-deficit/ hyperactivity disorder (ADHD) is one of the increasing neurodevelopmental disorders. In this study, by compiling the evidence from available meta-analyses, an umbrella systematic review was performed for neonatal risk factors associated with ADHD. Databases including PubMed, Scopus and Web of sciences were searched for retrieving eligible studies. Only systematic reviews were included in the study. Using a random-effect model, 95% prediction intervals were reported for each risk factor. Three studies were included in the review. The results showed that risk factors such as congenital heart disease (CHD), incomplete breastfeeding, low birth weight, and Apgar score < 7 at 5 minutes were significant risk factors for ADHD symptoms. However, the quality of included systematic reviews was low to moderate and the level of credibility for evidence was at most suggestive to weak. This umbrella review proposed that congenital anomalies, short duration or incomplete breastfeeding, low birth weight, and low Apgar score were all important factors for the manifestation of ADHD symptoms. However, the inclusion of more high-quality studies is needed for a conclusion.

Concepts Keywords
Breastfeeding ADHD
Drugs neonatal
Neurodevelopmental risk factors
Umbrella umbrella review


Type Source Name
disease MESH ADHD
disease MESH neurodevelopmental disorders
disease MESH congenital heart disease
disease MESH anomalies

Original Article

(Visited 1 times, 1 visits today)

Leave a Comment

Your email address will not be published. Required fields are marked *