Cardiac MRI Findings in Patients Clinically Referred for Evaluation of Post-Acute Sequelae of SARS-CoV-2 Infection.

Publication date: Jun 26, 2023

Persistent or recurrent cardiovascular symptoms have been identified as one of the hallmarks of long-COVID or post-acute sequelae of SARS-CoV-2 infection (PASC). The purpose of this study was to determine the prevalence and extent of cardiac abnormalities in patients referred for cardiac MRI due to clinical evidence of PASC. To investigate this, two tertiary care hospitals identified all patients who were referred for cardiac MRI under the suspicion of PASC in a 2-year period and retrospectively included them in this study. Patients with previously known cardiac diseases were excluded. This resulted in a total cohort of 129 patients (63, 51% female; age 41 +/- 16 years). The majority of patients (57%) showed normal cardiac results. No patient had active myocarditis or an acute myocardial infarction. However, 30% of patients had evidence of non-ischemic myocardial fibrosis, which exceeds the prevalence in the normal adult population and suggests that a possible history of myocarditis might explain persistent symptoms in the PASC setting.

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Concepts Keywords
Cardiovascular cardiac magnetic resonance
Covid long-COVID
Female PASC


Type Source Name
disease MESH Post-Acute Sequelae of SARS-CoV-2 Infection
disease MESH abnormalities
disease MESH cardiac diseases
disease MESH myocarditis
disease MESH fibrosis
disease VO population
disease IDO history
disease MESH Sequelae
disease MESH SARS CoV 2 Infection
disease MESH tachycardia
disease MESH chest pain
disease MESH inflammation
drug DRUGBANK Coenzyme M
disease MESH infection
drug DRUGBANK Gadolinium
disease MESH edema
disease VO volume
disease MESH myocardial infarction
drug DRUGBANK Methionine

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