Complications of SARS-CoV-2 Infection During Cardiac Rehabilitation: A Case Series.

Publication date: Jul 15, 2023

Vaccination strongly reduces the risk of hospitalization and death due to coronavirus disease 2019 (COVID-19). However, the severity of the acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and the degree of protection exerted over time by vaccination remains to be fully elucidated among hospitalized comorbid and vulnerable patients with SARS-CoV-2 infection. We report a case series of nine hospitalized vulnerable patients who developed a SARS-CoV-2 infection during a cardiac rehabilitation inpatient program. Age ranged from 50 to 81 years. All but one patient had received at least three doses of anti-COVID-19 vaccine more than 4 months before the cardiac event. Indications for cardiac rehabilitation included acute coronary syndromes, congestive heart failure, heart valve surgery, and coronary artery bypass graft. After the confirmed diagnosis of SARS-CoV-2 infection, all patients developed symptoms. Eight patients developed at least one SARS-CoV-2-related complication, including a significant increase in high-sensitivity troponin I levels, new-onset hypoxemia, persistent atrial fibrillation, non-sustained ventricular tachycardia and recurrent sinus arrest, pericardial effusion, and a persistent increase in blood pressure. Almost all patients developed complications which, however, did not evolve towards more severe expressions of the disease. These data suggest that even in this new phase of the pandemic, vaccination may exert a potential role to reduce the risk of progression towards more severe disease of SARS-CoV-2 infection in vulnerable patients with cardiovascular comorbidities.

Concepts Keywords
4months Cardiac rehabilitation
81years Complications
Cardiac Coronavirus disease 2019 (COVID-19)
Coronavirus Therapy
Hospitalization Vaccination


Type Source Name
disease MESH Complications
disease MESH SARS-CoV-2 Infection
pathway REACTOME SARS-CoV-2 Infection
disease VO vaccination
disease MESH death
disease MESH syndrome
disease MESH infection
disease VO time
disease VO report
disease VO age
disease VO COVID-19 vaccine
disease MESH cardiac event
disease MESH acute coronary syndromes
disease MESH congestive heart failure
disease MESH persistent atrial fibrillation
disease MESH ventricular tachycardia
disease MESH pericardial effusion
disease IDO blood

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