Epidemiological Profile of Hospitalized Patients with Cystic Fibrosis in Brazil Due to Severe Acute Respiratory Infection during the COVID-19 Pandemic and a Systematic Review of Worldwide COVID-19 in Those with Cystic Fibrosis.

Publication date: Jul 04, 2023

Since the onset of the coronavirus disease, COVID-19 pandemic, concern arose for those who might be at higher risk of a worse COVID-19 prognosis, such as those with cystic fibrosis (CF). In this context, we evaluated the features of hospitalized patients with CF due to severe acute respiratory infection (SARI) in Brazil and we also performed a systematic review including all the studies published from the beginning of the first case of COVID-19 (17 November 2019) to the date of this search (23 May 2022) which included, concomitantly, patients with CF and COVID-19 in the worldwide population. In our Brazilian data, we evaluated the period from December 2019 to March 2022, and we included 33 demographical and clinical patients’ features. We classified the patients into groups: (G1) SARI due to another viral infection than severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (23; 5. 4%), (G2) SARI due to an unknown etiological agent (286; 67. 1%), and (G3) SARI due to SARS-CoV-2 infection (117; 27. 5%). The individuals in G3 tended to be older, especially over 50 years old, and presented a higher prevalence of dyspnea, peripheral capillary oxygen saturation (SpO)

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Concepts Keywords
Brazil Brazil
Coronavirus CFTR
Healthcare epidemiology
Severe mucoviscidosis
systematic review


Type Source Name
disease MESH Cystic Fibrosis
disease MESH Infection
disease MESH COVID-19 Pandemic
pathway KEGG Coronavirus disease
disease VO population
disease MESH viral infection
disease VO Severe acute respiratory syndrome coronavirus 2
pathway REACTOME SARS-CoV-2 Infection
drug DRUGBANK Oxygen
drug DRUGBANK Coenzyme M
disease MESH Nosocomial infection
disease MESH Sore throat
drug DRUGBANK Oseltamivir
drug DRUGBANK Zanamivir
disease MESH death
disease MESH Asthma
pathway KEGG Asthma
disease MESH Diabetes mellitus
disease MESH Obesity
disease MESH syndrome
disease IDO symptom

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