Long-term effects of subthalamic nucleus deep brain stimulation on speech in Parkinson’s disease.

Publication date: Jul 15, 2023

Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment in advanced Parkinson’s Disease (PD). However, the effects of STN-DBS on speech are still debated, particularly in the long-term follow-up. The objective of this study was to evaluate the long-term effects of bilateral STN-DBS on speech in a cohort of advanced PD patients treated with bilateral STN-DBS. Each patient was assessed before surgery through a neurological evaluation and a perceptual-acoustic analysis of speech and re-assessed in the long-term in different stimulation and drug conditions. The primary outcome was the percentage change of speech intelligibility obtained by comparing the postoperative on-stimulation/off-medication condition with the preoperative off-medication condition. Twenty-five PD patients treated with bilateral STN-DBS with a 5-year follow-up were included. In the long-term, speech intelligibility stayed at the same level as preoperative values when compared with preoperative values. STN-DBS induced a significant acute improvement of speech intelligibility (p 

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Concepts Keywords
Acoustic Advanced
Cohort Bilateral
Drug Brain
Parkinson Dbs
Surgery Deep


Type Source Name
drug DRUGBANK Coenzyme M
disease MESH dysarthria
disease MESH Stroke
drug DRUGBANK Levodopa
disease MESH Parkinson disease
pathway KEGG Parkinson disease
disease MESH gait
drug DRUGBANK Apomorphine
disease MESH complications
drug DRUGBANK L-Leucine
drug DRUGBANK Trihexyphenidyl
drug DRUGBANK Profenamine
disease MESH Parkinsonism
disease MESH Speech disorders
disease MESH voice disorders
disease MESH progressive supranuclear palsy
disease MESH multiple system atrophy
disease MESH movement disorder
pathway REACTOME Reproduction

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