Publication date: Jul 15, 2023
Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment in advanced Parkinson’s Disease (PD). However, the effects of STN-DBS on speech are still debated, particularly in the long-term follow-up. The objective of this study was to evaluate the long-term effects of bilateral STN-DBS on speech in a cohort of advanced PD patients treated with bilateral STN-DBS. Each patient was assessed before surgery through a neurological evaluation and a perceptual-acoustic analysis of speech and re-assessed in the long-term in different stimulation and drug conditions. The primary outcome was the percentage change of speech intelligibility obtained by comparing the postoperative on-stimulation/off-medication condition with the preoperative off-medication condition. Twenty-five PD patients treated with bilateral STN-DBS with a 5-year follow-up were included. In the long-term, speech intelligibility stayed at the same level as preoperative values when compared with preoperative values. STN-DBS induced a significant acute improvement of speech intelligibility (p
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| Concepts | Keywords |
|---|---|
| Acoustic | Advanced |
| Cohort | Bilateral |
| Drug | Brain |
| Parkinson | Dbs |
| Surgery | Deep |
| Intelligibility | |
| Long | |
| Nucleus | |
| Parkinson | |
| Preoperative | |
| Speech | |
| Stimulation | |
| Stn | |
| Subthalamic | |
| Term |
Semantics
| Type | Source | Name |
|---|---|---|
| drug | DRUGBANK | Coenzyme M |
| disease | MESH | dysarthria |
| disease | MESH | Stroke |
| drug | DRUGBANK | Levodopa |
| disease | MESH | Parkinson disease |
| pathway | KEGG | Parkinson disease |
| disease | MESH | gait |
| drug | DRUGBANK | Apomorphine |
| disease | MESH | complications |
| drug | DRUGBANK | L-Leucine |
| drug | DRUGBANK | Trihexyphenidyl |
| drug | DRUGBANK | Profenamine |
| disease | MESH | Parkinsonism |
| disease | MESH | Speech disorders |
| disease | MESH | voice disorders |
| disease | MESH | progressive supranuclear palsy |
| disease | MESH | multiple system atrophy |
| disease | MESH | movement disorder |
| pathway | REACTOME | Reproduction |