The Prediction Score of Acute Kidney Injury in Patients with Severe COVID-19 Infection.

Publication date: Jun 30, 2023

The incidence and risk factors for acute kidney injury in COVID-19 patients vary across studies, and predicting models for AKI are limited. This study aimed to identify the risk factors for AKI in severe COVID-19 infection and develop a predictive model for AKI. Data were collected from patients admitted to the ICU at Thammasat University Hospital in Thailand with PCR-confirmed COVID-19 between 1 January 2021, and 30 June 2022. Among the 215 severe-COVID-19-infected patients, 102 (47. 4%) experienced AKI. Of these, 45 (44. 1%), 29 (28. 4%), and 28 (27. 4%) patients were classified as AKI stage 1, 2, and 3, respectively. AKI was associated with 30-day mortality. Multivariate logistic regression analysis revealed that prior diuretic use (odds ratio [OR] 7. 87, 95% confidence interval [CI] 1. 98-31. 3; p = 0. 003), use of a mechanical ventilator (MV) (OR 5. 34, 95%CI 1. 76-16. 18; p = 0. 003), and an APACHE II score ≥ 12 (OR 1. 14, 95%CI 1. 05-1. 24; p = 0. 002) were independent risk factors for AKI. A predictive model for AKI demonstrated good performance (AUROC 0. 814, 95%CI 0. 757-0. 870). Our study identified risk factors for AKI in severe COVID-19 infection, including prior diuretic use, an APACHE II score ≥ 12, and the use of a MV. The predictive tool exhibited good performance for predicting AKI.

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Concepts Keywords
Apache acute kidney injury
January COVID-19
June prediction
Kidney risk factors


Type Source Name
disease MESH Acute Kidney Injury
disease MESH COVID-19
disease MESH Infection
drug DRUGBANK Coenzyme M
disease MESH upper respiratory tract infection
disease MESH acute respiratory distress syndrome
disease MESH pneumonia
disease MESH non communicable diseases
disease MESH hypertension
disease MESH heart failure
disease MESH cardiovascular disease
disease MESH chronic obstructive pulmonary disease
disease VO effective
drug DRUGBANK Methionine
drug DRUGBANK Oxygen
drug DRUGBANK Medical air
disease MESH morbidities
drug DRUGBANK Creatinine
disease IDO process
disease MESH metabolic acidosis
disease MESH hypoalbuminemia
drug DRUGBANK Potassium

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