Publication date: Jun 30, 2023
The incidence and risk factors for acute kidney injury in COVID-19 patients vary across studies, and predicting models for AKI are limited. This study aimed to identify the risk factors for AKI in severe COVID-19 infection and develop a predictive model for AKI. Data were collected from patients admitted to the ICU at Thammasat University Hospital in Thailand with PCR-confirmed COVID-19 between 1 January 2021, and 30 June 2022. Among the 215 severe-COVID-19-infected patients, 102 (47. 4%) experienced AKI. Of these, 45 (44. 1%), 29 (28. 4%), and 28 (27. 4%) patients were classified as AKI stage 1, 2, and 3, respectively. AKI was associated with 30-day mortality. Multivariate logistic regression analysis revealed that prior diuretic use (odds ratio [OR] 7. 87, 95% confidence interval [CI] 1. 98-31. 3; p = 0. 003), use of a mechanical ventilator (MV) (OR 5. 34, 95%CI 1. 76-16. 18; p = 0. 003), and an APACHE II score ≥ 12 (OR 1. 14, 95%CI 1. 05-1. 24; p = 0. 002) were independent risk factors for AKI. A predictive model for AKI demonstrated good performance (AUROC 0. 814, 95%CI 0. 757-0. 870). Our study identified risk factors for AKI in severe COVID-19 infection, including prior diuretic use, an APACHE II score ≥ 12, and the use of a MV. The predictive tool exhibited good performance for predicting AKI.
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| Concepts | Keywords |
|---|---|
| Apache | acute kidney injury |
| January | COVID-19 |
| June | prediction |
| Kidney | risk factors |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | Acute Kidney Injury |
| disease | MESH | COVID-19 |
| disease | MESH | Infection |
| drug | DRUGBANK | Coenzyme M |
| disease | MESH | upper respiratory tract infection |
| disease | MESH | acute respiratory distress syndrome |
| disease | MESH | pneumonia |
| disease | MESH | non communicable diseases |
| disease | MESH | hypertension |
| disease | MESH | heart failure |
| disease | MESH | cardiovascular disease |
| disease | MESH | chronic obstructive pulmonary disease |
| disease | VO | effective |
| drug | DRUGBANK | Methionine |
| drug | DRUGBANK | Oxygen |
| drug | DRUGBANK | Medical air |
| disease | MESH | morbidities |
| drug | DRUGBANK | Creatinine |
| disease | IDO | process |
| disease | MESH | metabolic acidosis |
| disease | MESH | hypoalbuminemia |
| drug | DRUGBANK | Potassium |