Autoreactive T cells of ankylosing spondylitis elicited by COVID-19 infection: A snapshot of autoimmune imprinting and immunological host defense.

Publication date: Jul 14, 2023

The evolutionary emergence of adaptive immunity has significantly extended the lifespan of humans and other species. The adaptive immune system is essential for host survival and adaptation to the rapidly changing environment, however, it also leads to self-antigen recognition that creates the risk of autoimmune disease. However, it is difficult to trace back to the initial causative event of pathogen infection that occurs long before the clinical onset of autoimmune disease. The recognitions of foreign-and self-antigens are faithfully registered by the individual’s immune repertoire. In this study, through interrogating 1414 T-cell repertoires collected during the COVID-19 pandemic, we sought to trace the immunological host defense against COVID-19 infection, while investigating whether such disturbance of T-cell repertoire will lead to auto-reactive T cells. The percentages of ankylosing spondylitis (AS)-specific T cells were significantly increased with increasing COVID-19-specific T cells (p 

Concepts Keywords
Covid Ankylosing spondylitis
Host Autoimmune imprinting
Long COVID-19 infection
Pandemic Immunological host defense


Type Source Name
disease MESH ankylosing spondylitis
disease MESH COVID-19
disease MESH infection
disease IDO host
pathway REACTOME Adaptive Immune System
disease MESH autoimmune disease
disease IDO pathogen
disease IDO cell

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