The early excitatory action of striatal cholinergic-GABAergic microcircuits conditions the subsequent GABA inhibitory shift.

Publication date: Jul 14, 2023

Cholinergic interneurons of the striatum play a role in action selection and associative learning by activating local GABAergic inhibitory microcircuits. We investigated whether cholinergic-GABAergic microcircuits function differently and fulfill a different role during early postnatal development, when GABA actions are not inhibitory and mice pups do not walk. We focused our study mainly on dual cholinergic/GABAergic interneurons (CGINs). We report that morphological and intrinsic electrophysiological properties of CGINs rapidly develop during the first post-natal week. At this stage, CGINs are excited by the activation of GABA receptors or GABAergic synaptic inputs, respond to cortical stimulation by a long excitation and are linked by polysynaptic excitations. All these excitations are replaced by inhibitions at P12-P15. Early chronic treatment with the NKCC1 antagonist bumetanide to evoke premature GABAergic inhibitions from P4 to P8, prevented the GABA polarity shift and corticostriatal pause response at control postnatal days. We propose that early excitatory cholinergic-GABAergic microcircuits are instrumental in the maturation of GABAergic inhibition.

Open Access PDF

Concepts Keywords
Corticostriatal Action
P12 Cgins
Postnatal Cholinergic
Pups Early
Rapidly Excitations


Type Source Name
drug DRUGBANK gamma-Aminobutyric acid
drug DRUGBANK Bumetanide
drug DRUGBANK Coenzyme M
drug DRUGBANK Acetylcholine
drug DRUGBANK Chloride ion
drug DRUGBANK Trestolone
drug DRUGBANK Dimethyl sulfoxide
drug DRUGBANK Picrotoxin
drug DRUGBANK L-Tyrosine
drug DRUGBANK Mecamylamine
drug DRUGBANK Somatostatin
drug DRUGBANK Neuropeptide Y
drug DRUGBANK Calcium
drug DRUGBANK Glutamic Acid
drug DRUGBANK Ketamine
drug DRUGBANK Isoxaflutole
drug DRUGBANK Water
drug DRUGBANK Phosphocreatine
drug DRUGBANK Potassium Chloride
drug DRUGBANK Aspartame
drug DRUGBANK Lysergic acid diethylamide
drug DRUGBANK Proline
drug DRUGBANK (S)-Des-Me-Ampa
disease MESH Parkinson disease
pathway KEGG Parkinson disease
drug DRUGBANK Choline
drug DRUGBANK Dopamine
drug DRUGBANK Guanosine
drug DRUGBANK Trihexyphenidyl
drug DRUGBANK Profenamine
disease MESH autism

Original Article

(Visited 1 times, 1 visits today)

Leave a Comment

Your email address will not be published. Required fields are marked *