Publication date: Aug 01, 2023
There are significantly fewer options for the treatment of bipolar depression than major depressive disorder, with an urgent need for alternative therapies. In this pilot study, we treated six subjects with bipolar disorder types I and II (according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria) who had been in a current depressive episode for at least four weeks. Four subjects were female (66. 66%), and the mean age was 45. 33 (+/-12. 32). Subjects received adjunct treatment with two arketamine intravenous infusions one week apart-0. 5 mg/kg first and then 1 mg/kg. The mean baseline Montgomery-Asberg Depression Rating Scale (MADRS) total score was 36. 66, which decreased to 27. 83 24h after the first infusion of 0. 5 mg/kg of arketamine (p = 0. 036). In respect of the 1 mg/kg dose, the mean MADRS total score before the second infusion was 32. 0, which dropped to 17. 66 after 24h (p
| Concepts | Keywords |
|---|---|
| 5mg | Antidepressant |
| Depressive | Arketamine |
| Intravenous | Bipolar depression |
| Pilot | Bipolar disorder |
| Week | Glutamate |
| Ketamine | |
| Major depression | |
| NMDA |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | MESH | bipolar depression |
| disease | MESH | major depressive disorder |
| disease | MESH | Mental Disorders |
| drug | DRUGBANK | Ketamine |