Development of Accurate Long-lead COVID-19 Forecast.

Publication date: Jul 17, 2023

Coronavirus disease 2019 (COVID-19) will likely remain a major public health burden; accurate forecast of COVID-19 epidemic outcomes several months into the future is needed to support more proactive planning. Here, we propose strategies to address three major forecast challenges, i. e., error growth, the emergence of new variants, and infection seasonality. Using these strategies in combination we generate retrospective predictions of COVID-19 cases and deaths 6 months in the future for 10 representative US states. Tallied over >25,000 retrospective predictions through September 2022, the forecast approach using all three strategies consistently outperformed a baseline forecast approach without these strategies across different variant waves and locations, for all forecast targets. Overall, probabilistic forecast accuracy improved by 64% and 38% and point prediction accuracy by 133% and 87% for cases and deaths, respectively. Real-time 6-month lead predictions made in early October 2022 suggested large attack rates in most states but a lower burden of deaths than previous waves during October 2022 -March 2023; these predictions are in general accurate compared to reported data. The superior skill of the forecast methods developed here demonstrate means for generating more accurate long-lead forecast of COVID-19 and possibly other infectious diseases.

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Concepts Keywords
Diseases Accurate
Month Burden
Proactive Coronavirus


Type Source Name
disease MESH COVID-19
disease MESH infection
disease VO time
disease MESH infectious diseases
disease IDO history
disease IDO process
pathway REACTOME Reproduction
drug DRUGBANK Coenzyme M
disease MESH Allergy
disease VO population
drug DRUGBANK Cysteamine
disease MESH influenza
disease MESH uncertainty
disease VO vaccination
disease IDO susceptibility
disease VO Viruses
drug DRUGBANK Tretamine
disease VO Optaflu
disease MESH death
disease IDO virulence
disease VO vaccine
disease VO vaccine effectiveness
disease MESH imported infections
disease VO effectiveness
disease VO vaccinated
disease VO immunized
disease VO dose
drug DRUGBANK Ranitidine
drug DRUGBANK L-Valine
disease IDO algorithm
disease VO USA
disease MESH Viral Infections
disease VO inactivation
disease VO viability

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