Role of Non-Receptor-Type Tyrosine Phosphatases in Brain-Related Diseases.

Publication date: Jul 17, 2023

The non-receptor protein tyrosine phosphatase is a class of enzymes that catalyze the dephosphorylation of phosphotyrosines in protein molecules. They are involved in cellular signaling by regulating the phosphorylation status of a variety of receptors and signaling molecules within the cell, thereby influencing cellular physiological and pathological processes. In this article, we detail multiple non-receptor tyrosine phosphatase and non-receptor tyrosine phosphatase genes involved in the pathological process of brain disease. These include PTPN6, PTPN11, and PTPN13, which are involved in glioma signaling; PTPN1, PTPN5, and PTPN13, which are involved in the pathogenesis of Alzheimer’s disease Tau protein lesions, PTPN23, which may be involved in the pathogenesis of Epilepsy and PTPN1, which is involved in the pathogenesis of Parkinson’s disease. The role of mitochondrial tyrosine phosphatase in brain diseases was also discussed. Non-receptor tyrosine phosphatases have great potential for targeted therapies in brain diseases and are highly promising research areas.

Concepts Keywords
Alzheimer Alzheimer’s disease
Enzymes Epilepsy
Neurobiol Glioblastoma
Ptpn13 Non-receptor tyrosine phosphatases
Ptpn6 Parkinson’s disease
Traumatic brain injury


Type Source Name
drug DRUGBANK L-Tyrosine
disease MESH pathological processes
disease MESH brain disease
disease MESH glioma
pathway KEGG Glioma
disease MESH pathogenesis
disease MESH Epilepsy
disease MESH Glioblastoma

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