Coronavirus disease 2019 in a patient with pulmonary fibrosis and emphysema: An autopsy report.

Publication date: Nov 01, 2023

Various diseases (e. g., hypertension and diabetes) are risk factors for the exacerbation of coronavirus 2019 (COVID-19). Patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) tend to develop severe COVID-19. Patients with severe COVID-19 present with acute respiratory distress syndrome (ARDS), and many COVID-19-related ARDS survivors eventually develop fibrosis. However, the appropriate management of patients with COVID-19 and ILD and post-COVID-19 ILD remains unclear. Thus, a better understanding of the pathology that exacerbates COVID-19 in patients with ILD is needed. We report the autopsy results of a patient with COVID-19 and combined pulmonary fibrosis and emphysema, whose lung organization and fibrosis progressed after the acute phase of infection. Histopathological findings suggest that fatal pulmonary fibrosis persists after the negative conversion of SARS-CoV-2. Elucidating the cause of death by autopsy may help determine therapeutic strategies in patients with COVID-19 and ILD. Vaccination and early administration of anti-inflammatory drugs or antifibrotic agents may be crucial for preventing disease progression and fatal lung fibrosis. This report aims to clarify the histopathological features of COVID-19 in patients with ILD via autopsy and discuss treatment strategies.

Concepts Keywords
Autopsy Autopsy
Coronavirus COVID-19
Diabetes Interstitial lung disease
Early SARS-CoV-2


Type Source Name
disease MESH Coronavirus disease 2019
disease MESH pulmonary fibrosis
disease MESH emphysema
disease VO report
disease MESH hypertension
disease MESH chronic obstructive pulmonary disease
disease MESH interstitial lung disease
disease MESH acute respiratory distress syndrome
disease MESH fibrosis
drug DRUGBANK Tropicamide
disease VO organization
disease MESH infection
disease MESH cause of death
disease VO vaccination
disease MESH disease progression

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