Population fraction of Parkinson’s disease attributable to preventable risk factors.

Publication date: Dec 05, 2023

Parkinson’s disease is the fastest-growing neurologic disease with seemingly no means of prevention. Intrinsic risk factors (age, sex, and genetics) are inescapable, but environmental factors are not. We identified repeated blows to the head in sports/combat as a potential new risk factor. 23% of PD cases in females were attributable to pesticide/herbicide exposure, and 30% of PD in males were attributable to pesticides/herbicides, military-related chemical exposures, and repeated blows to the head, and therefore could have potentially been prevented.

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Concepts Keywords
Fastest Attributable
Females Blows
Genetics Factors
Herbicide Fastest
Parkinson Fraction


Type Source Name
disease MESH Parkinson’s disease
drug DRUGBANK Platelet Activating Factor
disease MESH weight loss
disease MESH rapid eye movement sleep behavior disorder
disease MESH causality
drug DRUGBANK Isoxaflutole
drug DRUGBANK Coenzyme M
disease MESH behavioral problems
disease MESH dementia
disease MESH chronic traumatic encephalopathy
drug DRUGBANK Water
disease MESH malaria
pathway KEGG Malaria
disease MESH lifestyle
disease MESH movement disorder
disease MESH stroke
disease MESH ataxia
disease MESH multiple sclerosis
disease MESH Alzheimer’s disease
disease MESH autism
disease MESH bipolar disorder
disease MESH amyotrophic lateral sclerosis
pathway KEGG Amyotrophic lateral sclerosis
disease MESH epilepsy
disease MESH COVID 19 pandemic
drug DRUGBANK Etoperidone
disease MESH Parkinsonism
pathway REACTOME Reproduction

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