Endothelial extracellular vesicles enriched in microRNA-34a predict new-onset diabetes in COVID-19 patients: novel insights for long-COVID metabolic sequelae.

Publication date: Feb 09, 2024

Emerging evidence indicates that the relationship between COVID-19 and diabetes is twofold: 1) it is known that the presence of diabetes and other metabolic alterations poses a considerably high risk to develop a severe COVID-19; 2) patients who survived a SARS-CoV-2 infection have an increased risk of developing new-onset diabetes. However the mechanisms underlying this association are mostly unknown and there are no reliable biomarkers to predict the development of new-onset diabetes. In the present study, we demonstrate that a specific microRNA (miR-34a) contained in circulating extracellular vesicles released by endothelial cells reliably predicts the risk of developing new-onset diabetes in COVID-19. This association was independent of age, sex, BMI, hypertension, dyslipidemia, smoking status, and D-dimer. Significance Statement We demonstrate for the first time that a specific microRNA (miR-34a) contained in circulating extracellular vesicles released by endothelial cells is able to reliably predict the risk of developing new-onset diabetes mellitus after having contracted COVID-19. Strikingly, this association was independent of age, sex, BMI, hypertension, dyslipidemia, smoking status, and D-dimer. Our findings are also relevant when considering the emerging importance of post-acute sequelae of COVID-19, with systemic manifestations observed even months after viral negativization (Long-COVID).

Concepts Keywords
Biomarkers cardiac metabolism
Covid Cardiac myocytes
Diabetes endothelial cells
New MicroRNA
Viral

Semantics

Type Source Name
disease MESH COVID-19
disease MESH sequelae
pathway REACTOME SARS-CoV-2 Infection
disease MESH hypertension
disease MESH dyslipidemia
disease VO time
disease MESH diabetes mellitus

Original Article

(Visited 1 times, 1 visits today)

Leave a Comment

Your email address will not be published. Required fields are marked *